Systemic disease and the mouth / OFG Flashcards

1
Q

What 2 types of manifestation of systemic disease on teeth?

A
  • Disruption of the tooth structure formation
  • Disruption to the tooth structure content
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2
Q

What two congenital conditions or infection can cause disturbance of the tooth structure?

A
  • Syphilis , TORCH
  • Ectodermal dysplasia
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3
Q

What are two substances causes tooth pigmentation if found in the blood?

A
  • Bilirubin
  • Tetracycline
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4
Q

What causes this?

A

Ectodermal dysplasia

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5
Q

What causes this?

A

Syphilis

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6
Q

What causes this?

A

Perinatal illness

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7
Q

What causes this?

A

A metabolic disease called porphyria

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8
Q

What causes this?

A

Bilirubin

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9
Q

What causes this?

A

Tetracycline

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10
Q

5 mucosal effects that may be caused from systemic disease ?

A
  • Giant cell granulomas
  • Orofacial granulomatosis
  • Recurrent apthous ulceration
  • Dermatoses
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11
Q

What are the two types of giant cell lesions?

A
  • Central and peripheral
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12
Q

Which blood test is important to carry out for giant cell lesions and why?

A
  • Parathyroid test and calcium level as giant cell lesions could be a result of hypepararthyroidism leading to stimulation of osteoclasts
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13
Q

Other hyperthyroidism and trauma , give 3 conditions that may be a part in causing giant cell lesions

A
  • Renal Failure
  • Hypocalcaemia
  • parathyroid tumour
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14
Q

What is this pigmentation caused by?

A

Addison’s disease leading to raised ACTH

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15
Q

What are 3 effects of haematinic deficiencies?

A
  • ulceration and painful tongue
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16
Q

The presence of which protein is a good predictor of Crohn’s disease?

A

Faecal calprotectin

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17
Q

What dietary allergens may cause OFG?

A
  • Benzoate
  • Sorbate
  • Cinnamon
  • Chocolate
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18
Q

In which food is benzoates found?

A

Tomatoes

19
Q

How would you determine the dietary trigger to investigate OFG?

A

Dietary exclusion

20
Q

3 management options for orofacial granulomatosis?

A
  • 3 months empirical dietary exclusion
  • Topical treatment to angular cheilitis ( miconazole , hydrocortisone cream)
  • topical treatment to lip swelling (tacrolimus)
21
Q

4 connective tissue diseases (autoimmune) that can have implications on the oral cavity?

A
  • Systemic lupus erythematosis
  • Systemic sclerosis
  • Sjogren’s syndrome
  • Mixed connective tissue disease
22
Q

4 Signs of SLE in the mouth?

A
  • Ulcers
  • Angular cheilitis
  • Dry mouth
  • Gingivitis
23
Q

What is scleroderma (systemic sclerosis)?

A

An autoimmune disease characterised by hardening of the skin and the connective tissues, may attack the salivary glands causing dry mouth

24
Q

An example of large vessel disease

A

Temporal artritis

25
Q

An example of medium vessel disease?

A
  • Kawasaki disease
  • Polyarteritis nodosa
26
Q

An example of a small vessel disease?

A
  • Granulomatosis with polyangitis
27
Q

4 things that may cause haematinic deficiency

A
  • Poor intake - dietary analysis
  • Malabsorption - coeliac and Crohn’s disease
  • Blood loss - Crohn’s disease , Ulcerative Colitis , Peptic disease , liver disease and bowel cancer
  • Increased demand - childhood growth spurts
28
Q

Oral effects of medical therapy

A
  • Dry mouth
  • Oral ulceration
  • Lichenoid reaction
  • Angio-oedema
  • Osteonecrosis
29
Q

Define orofacial granulomatosis?

A
  • Clinical presentation of oedema in the oral and facial tissues due to blockage in lymphatic drainage due to an immune reaction
30
Q

What is angio-oedema ?

A

Oedema of the oral and facial tissues due to an increase of fluid exudate from the capillaries but with no lymphatic drainage

31
Q

What is the difference between OFG swelling and angio-oedema swelling?

A

Angio-oedema swelling comes up quickly and settles quickly whereas OFG swelling comes up quickly and settles slowly with changes in swelling intensity

32
Q

What other diseases that can cause giant cell that may present as OFG?

A
  • Crohn’s is the most common
  • Tuberculosis
  • Sarcoidosis
33
Q

What is this?

A

Angio-oedema

34
Q

1 histological sign in angio-oedema?

A
  • fluid within connective tissue bundles
35
Q

1 histological sign of OFG?

A

Giant cells

36
Q

What type of hypersensitivity reaction in angio-oedema?

A

1- caused by allergy

37
Q

What type of hypersensitivity reaction in OFG?

A

Type IV - a delayed hypersensitivity reaction

38
Q

What are multinuclear giant cells?

A

Fused macrophages

39
Q

How can sever OFG affect the life of a patient?

A
  • Issues with appearance at a very important part of child development
  • Often will lead to depression and isolation
40
Q

What do you measure in a child with OFG to monitor growth and if abnormality is detected , what would that imply?

A
  • Height and weight
  • Abonrmality implies nutritional deficiency which imply there is bowel problem
41
Q

two ways to detect if there there is a connection between OFG and Crohn’s other than the presence of faecal calprotectin?

A
  • GI symptoms
  • Start sequential growth monitoring
42
Q

What interlesional steroid that can be injected to treat Crohn’s ?

A
  • Triamcinolone
43
Q

What systemic treatment other than azathioprine and prednisolone can be used in severe OFG?

A

Azithromycin