Lichen planus Flashcards
What is lichen planus?
A chronic inflammatory immune mediated disease that affects the oral mucosa and skin
What is the most histological signs that is considered to be a diagnostic feature of lichen planus?
T-cell infilitrate into the basement membrane under the epidermis?
Other than a hugging band of lymphocytes at the basement membrane, Give 3 other histological signs of lichen planus?
- Orthokeratosis
- Civatte bodies
- Vacuoles at basal layer
What is the aetiology of lichen planus?
- Langerhans cells present an antigen that activates an immune response leading to t-cells attacking the body tissue
What are 4 triggers of lichen planus other than allergy to metals and drugs?
- Genetics
- Physical and emotional stress
- Injury to the skin
- Viral infections - herpes zoster and Hep C
If lichen planus occurs as a response of an injury to skin, what do we call this response?
isomorphic
If lichen planus occurs as a response of a localised skin disease such as herpes zoster, what do we call this response?
isotopic
What 2 group of drugs might trigger lichen planus?
- beta-blockers
- Ace inhibitors
What are the symptoms of lichen planus ?
- Often none
- sensitivity to hot and spice food
- Burning sensation in the mucosa
Other than the oral mucosa , give 4 areas which can be affected by lichen planus?
- Skin
- Scalp
- Genitals
- Hair and nails
What 4 sites in the oral mucosa that can be affected by lichen planus?
- buccal mucosa
- gingivae
- tongue
- lips
What is the commonest site for lichen planus in the oral mucosa?
buccal mucosa - at commissure , middle , around 3rd molar
What term can describe gingival lichen planus?
Desquamative gingivitis
If lichen planus affect the dorsum of the tongue, what might your clinical findings be? 2
- Loss of papilla
- Smooth tongue surface
If the lateral aspect of the tongue is affected by lichen planus by an isolated lesion, what might be the trigger?
Amalgam