Sympathetic Agonist Drugs (Sympathomimetics) Flashcards
isoproterenol
B1 and B2 agonist
DA at low doses
D1 and D2 agonist
DA at medium doses
B1 and B2 agonist
DA at high doses
A1 and A2 agonist
Dobutamine
B1 > B2 agonist
indications for dobutamine
used in stress tests and sometimes in heart failure–> increases HR and contractility
Phenylephrine
A1 selective agonist
phenylephrine uses
pupilary dilation and nasal decongestion
albuterol, levalbuterol, salmeterol
B2 > B1 agonist
used for asthma
Advantage of levalbuterol over albuterol and salmaterol
less tachycardia (more B2 specific)
terbutaline
B2 > B1 agonist
main use of terbutaline
tocolysis–> inhibits uterine contraction
Clonidine
A2 agonist–> decreses NE release; used for HTN
*issues with rebound hypertension
alpha-methyldopa; main use
A2 agonist–> used in pregnancy-induced HTN, like pre-eclampsia
3 indirect sympathetic agonist
- amphetamines
- Ephedrine
- cocaine
amphetamine and ephedrine MOA
release stored catecholamines
cocaine MOA
inhibits catecholamine reuptake
given in nebulizer for asthma
albuterol or levalbuterol
DOC for anaphylaxis
Epinephrine
MC first line agent for septic shock or cardiogenic shock
NE
NE
A1, A2, B1 agonist
Epinephrine
A1, A2, B1, B2 agonist
given subQ for asthma, etc
terbutaline–> remember, also mainly used for tocolysis, also given subQ for this = rapid onset
used by ENT to constrict nasal vessels
Phenylephrine, sometimes cocaine
Ritrodine
B2 selective agonist–> can be used to reduce premature uterine contractions
advantage of using clonidine or alpha methyldopa for HTN
HTN with kidney dz–> decrease hypertension with no decrease in blood flow to kidney
