Nephrosis and Nephritis (4-5 star)

Question 1

3 defining features of nephrotic syndrome

Answer 1

1. proteinuria over 3.5 g/day
2. hypoalbuminemia
3. peripheral edema

Question 2

findings in nephritic syndrome

Answer 2

1. hematuria
2. RBC casts
3. renal failure symptoms–> oliguria, azotemia, hypertension (due to salt retention)

Question 3

linear pattern of IgG deposition on IF

Answer 3

Goodpasture’s syndrome

Question 4

lumpy-bumpy deposits of IgG, IgM, and C3 in mesangium

Answer 4

Acute post-strep glomerulonephritis

Question 5

deposits of IgA in mesangium

Answer 5

Berger’s disease (IgA nephropathy)

Question 6

Anti-GBM abs, hematuria, hemoptysis

Answer 6

Goodpasture’s

Question 7

nephritis, deafness, catracts

Answer 7

Alport’s syndrome

Question 8

Crescent formation in glomeruli

Answer 8

Rapidly progressive glomerulonephritis

Question 9

wire-loop appearance on LM

Answer 9

Diffuse proliferative glomerulonephtitis (lupus-nephritis; “wire-lupus”)

Question 10

MC nephrotic syndrome in children

Answer 10

Minimal change disease

*often follows URI

Question 11

MC nephrotic syndrome in adults

Answer 11

Focal segmental glomerulonephritis

Question 12

effacement of foot processes on EM

Answer 12

minimal change disease

Question 13

nodular glomerulosclerosis

Answer 13

diabetic glomerulonephropathy

Question 14

nephtotic syndrome associated with Hep B

Answer 14

membranoproliferative glomerulonephritis

Question 15

nephrotic syndrome associated with HIV

Answer 15

Focal segmental glomerulosclerosis

Question 16

EM: subendothelial humps and tram-track appearance

Answer 16

membranoproliferative glomerulonephritis

Question 17

LM: segmental sclerosis and hyalinosis

Answer 17

Focal segmental glomerulonephritis

Question 18

purpura on back of legs and arma, abdominal pain, IgA nephropathy

Answer 18

Henoch-schlonlein purpura

Question 19

spike and domes on GBM due to electron dense subepithelial deposits

Answer 19

membranous nephropathy