Autoantibodies ( 4 stars!!) Flashcards

1
Q

Anti-IgG IgM Abs

A

Rheumtoid arthritis

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2
Q

Anti-citrullinated protein Abs (APCA)

A

Rheumatoid arthritis

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3
Q

Which RA Ab is more specific

A

ACPA

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4
Q

Anti-centromere Abs

A

CREST

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5
Q

Anti-DNA topoisomerase

A

diffuse scleroderma (also called anti-scl-70)

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6
Q

Anti-histone

A

Drug induced lupus

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7
Q

Antinuclear antibodies (ANA)

A

SLE

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8
Q

Anti-Smith

A

SLE

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9
Q

which SLE Ab is most specific

A

Anti-Smith–> ANA is a screen

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10
Q

Anti-ds DNA

A

Lupus nephritis

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11
Q

Anti-Jo-1

A

Polymyositis/Dermatomyositis

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12
Q

Anti-Ro

A

Sjogrens syndrome (also called Anti-SSA)

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13
Q

Anti-La

A

Sjogrens syndrome (also called anti-SSB)

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14
Q

Anti-U1-RNP

A

mixed connective tissue disease

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15
Q

anti-desmoglein

A

Pemphigus vulgaris

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16
Q

Anti-acetylcholine receptor

A

Myasthenia gravis

17
Q

Anti-endomysial (anti-tissue transglutamase)

A

Celiac disease

18
Q

Anti-gliadin

A

Celiac disease

19
Q

Anti-mitochondrial

A

Primary Biliary cirrhosis

20
Q

Anti-smooth muscle

A

autoimmune hepatitis

21
Q

Anti-glutamate decarboxylase

A

type I Diabetes

22
Q

Anti-thyrotropin receptor

A

Graves disease

23
Q

Anti-thyroid peroxidase

A

Hashimoto thyroiditis (also called anti-TPO)

24
Q

Anti-thyroglobulin

A

Hashimoto or Graves

25
Q

Anti-basement membrane

A

Goodpasture’s Syndrome

26
Q

c-ANCA

A

Granulomtosis w/ polyangitis (Wegner’s)

*this and Goodpastures affect lung and kidney

27
Q

p-ANCA (3)

A
  1. Pauci-immune crescenteric glomerulonephritis
  2. Churg-strauss syndrome
  3. Microscopic polyangiitis