Hypersensitivity types (4-5 star!!)

Question 1

Type I

Answer 1

free antigen binds IgG and causes histamin, bradykinin release= wheal and flare reaction

Question 2

Type II

Answer 2

antibody mediated cytotoxicity–> IgM or IgG bind to fixed antigen on a cell and activate complement–> MAC and cell detruction

Question 3

Type III

Answer 3

Immune complex–> IgG -antigen complex deposit in tissues and ativate complement there, recruiting neutrophils (C5a), incite inflammation

Question 4

Type IV

Answer 4

delayed, T-cell mediated–> sensitized T-cells encounter antigen and activate macrophages= NO Ab involved

Question 5

Acute hemolytic transfusion reaction

Answer 5

type II

Question 6

Acute rheumatic fever

Answer 6

type II

Question 7

Arthus reaction

Answer 7

type II–> is local subacute Ab-mediated HSN, usually due to injection of antigen, forming immune complexes in skin= edema, necrosis, activation of complement (occurs 4-12 hours after an immunization, etc)

Question 8

Asthma

Answer 8

type I

Question 9

contact dermatitis

Answer 9

type IV (nickel, cobalt allergy

Question 10

eczema

Answer 10

type I

Question 11

Graves disease

Answer 11

type II

Question 12

guillan-barre syndrome

Answer 12

type IV

Question 13

graft-vs-host disease

Answer 13

type IV

Question 14

hashimoto thyroiditis

Answer 14

type IV

Question 15

idiopathic thrombocytopenia (ITP)

Answer 15

type II

Question 16

multiple sclerosis (MS)

Answer 16

type IV

Question 17

myasthenia gravis

Answer 17

type II

Question 18

polyarteritis nodosa

Answer 18

type III

Question 19

post-streptococcal glomerulonephritis

Answer 19

type III

Question 20

rheumatoid arthritis

Answer 20

type III

Question 21

rhinitis

Answer 21

type I

Question 22

SLE

Answer 22

type III

Question 23

pernicious anemia

Answer 23

type II

Question 24

erythroblastosis fetalis

Answer 24

type II

Question 25

goodpasture’s syndrome

Answer 25

type II

Question 26

PPD skin test

Answer 26

type IV