Immunology--> cell markers, etc

Question 1

found on all T cells

Answer 1

1. CD3–> associated with TCR and necessary for signal transmission due to TCR binding
2. CD28 (binds B7)

Question 2

4 molecules on APC cell surface

Answer 2

1. MHC I
2. MHC II
3. B7
4. CD40

Question 3

what are B7 also called (CD… 2 numbers)

Answer 3

CD80 or CD86

Question 4

function of CD40 on APC

Answer 4

allows T-cells to activate APC

Question 5

3 types of cells with antigen presenting capacity

Answer 5

1. Dendritic cells–> in interstitium of all organs except brain
2. Langerhans cells (epidermal layers of skin)
3. B cells

Question 6

pathology of Langerhans cell histiocytosis

Answer 6

hyperproliferation of non-functional alngerhans cells (from monocyte lineage); can’t stimulate T-cells

Question 7

symptoms of Langerhans cell histiocytosis

Answer 7

child with lytic bone lesions and rash

Question 8

characterisistic EM finding in langerhans cell histiocytosis

Answer 8

Birbeck granules–> look like tennis rackets

Question 9

what two abnormal proteins do defective cells in langerhans cell histiocytosis express

Answer 9

1. S-100 –. main one to know, is a nueral crest marker

2. CD1a

Question 10

3 markers on T reg cells

Answer 10

1. CD3
2. CD4
3. CD25

Question 11

2 markers on helper T cells

Answer 11

1. CD4

2. CD40-L (binds CD40 on B cells, like the B7-CD40 costimulation)

Question 12

2 markers on NK cells

Answer 12

1. CD16

2. CD56 (unique T cell marker)

Question 13

function of CD16

Answer 13

binds to constant region of Abs–> allows for Antibody-dependent Cell-mediated Cytotoxocity (ADCC)

*also found on neutrophils and some macrophages/monocytes

Question 14

8 markers found on B cells

Answer 14

1. IgM
2. IgD
3. CD19
4. CD20
5. CD21
6. CD40
7. MHC II
8. B7 (CD80 or CD86)

Question 15

6 cell surface proteins found on macrophages

Answer 15

1. CD14
2. CD40
3. MHC II
4. B7
5. Fc and C3b-> enhanced phagocytosis