spinal cord - lesions / reflexes Flashcards
Characteristic of spinal cord lesions in Multiple sclerosis
- mostly white matter of cervical region
- random and asymmetric lesions
- demyelination
ALS means / AKA
amyotrophic lateral sclerosis (Lou Gehring disease)
ALS pathophysiology
defect in superoxide dismutase 1 –> combined UMN and LMN deficits with NO sensory, occulomotor deficits, bowel, bladder or sensory deficits
ALS - deficits
combined UMN and LMN deficits with no sensory or occulomotor deficits
NO SENSORY OR BOWEL BLADDER DEFICITS
ALS - mutation in
superoxide dismutase 1
ALS - clinical signs
both UMN and LMN signs
ALS - treatment
Riluzole
Riluzole action on ALS / mechanism of action
modestly increases survival by decrease glutamate excitotoxicity
ALS - common presentation
asymmetric limb weakness (hands/feet), fasciculations, eventual atrophy
spinal cord lesions - complete inclusion of anterior spinal artery
spares dorsal columns and Lissaeuer tract
watershed area of anterior spinal cord (why)
upper throracic ASA territory, as Adamkiewicz artery supplies ASA below T8
Adamkiewicz artery supplies ASA … (area)
below T8
…… supplies ASA below T8
Adamkiewicz artery
Tabes dorsalis is caused by
3 syphilis
tabes dorsasis - spinal cord lesion?
degeneration (DEMYELINATION) of dorsal columns and roots
tabes dorsasis –> …. (results)
- impaired sensation proprioception
2. progressive sensory ataxia
tabes dorsalis - progressive sensory ataxia
inability to sense or feel legs –> poor coordination
tabes dorsalis is associated with
- Charcot joints
- shooting pain (paresthesias)
- Argyll Robertson pupils
Charcot joints is also called
Neuropathic arthropathy
Charcot joints refers to
progressive degeneration of a weight bearing joint, a process marked by bony destruction, bone resorption, and eventual deformity.
Argyll Robertson pupils
are bilateral small pupils that reduce in size on a near object (accommodate) they do not “react” to light
Argyll Robertson pupils is AKA
prostitute’s pupils
tabes dorasil - clinical examination
- absence of Deep Tendon Reflexes
- Romberg sign (+)
- Argyll Robertson
- Stroke without hypertension
Syringomyelia - definition
syrinx expands and damage ANTERIOR WHITE COMMISSURE of spinothalamic tract (2nd neurons) –> can expand and affect other tracts
Syringomyelia - symptoms (and area) / seen with
bilteral loss of pain and temperature
usually C8-T1 –> cape - like
seen with Chiari I malformation
vitamin B12 deficiency - spinal cord lesions
sabacute combined degeneration –> demyelination of dorsal column, lateral corticospinal tracts, and spinocerebellar tracts
vitamin B12 deficiency - symptoms because of spinal cord lesions
- ataxic gaits
- paresthesia
- impaired progression and vibration sense
- weakness
poliomyelitis is caused by / root of transmission
poliovirus / fecal-oral
poliovirus to CNS (direction)
Replicates in oropharynx and small intestine before spreading via bloodstream to CNS
poliomyelitis - pathophysiology
infection causes destruction in anterior horn of spinal cord (LMN death)
poliomyelitis - death of … cells
LMN
poliomyelitis - signs and symptoms
- signs of infection –> malaise, headache, fever, nausea
2. LMN lesion signs –> weakness, hypotonia, flaccid paralysis, fasciculations, hyporeflexia, muscle atrophy
Werding-Hoffman disease is also called
Spinal mascular atrophy
poliomyelitis - virus recovered from
stool or throat
poliomyelitis - labs
- CSF: increase WBCs and slight increase of protein, no change of glucose
- virus recovered from stool or throat
poliomyelitis - glucose in CSF
no change
Spinal mascular atrophy is also called
Werding-Hoffman disease
Spinal mascular atrophy (Werding-Hoffman disease) - pathophysiology / mode of inheritance
congenital degeneration of anterior horns of spinal horn –> LMN lesion AR
Spinal mascular atrophy (Werding-Hoffman disease) - common appearance
floppy baby with marked hypotonia and tongue fasciculations
Spinal mascular atrophy (Werding-Hoffman disease) - prognosis
infantile type –> median age of death of 7 months