Sleep physiology Flashcards
Sleep cycle is regulated by …. , which is driven by ….
circadian rhythm
suprachiasmatic nucleus of hypothalamus
circadian rhythm controls …
noctural release of ACTH, prolactin, melatonin, norepinephrine
suprachiasmatic nucleus of hypothalamus is regulated by
environment (eg. light)
suprachiasmatic nucleus of hypothalamus - melatonin secretion regulation
environment (eg. light) –> suprachiasmatic nucleus of hypothalamus –> norepinephrine release –> pineal gland –> melatonin
stage of sleep
- rapid-eye movement (REM)
2. non-REM
REM special feature
extraocular movements during REM
REM - extraocular movements is due to
activity of paramedian pontine reticular formation/conjugate gaze center
REM - duration
increases through the night
REM occurs every
90 mins
benzodiazepines clinical use in sleep
- night terrors
2. sleepwalking
treat bedwetting (sleep enuresis) with
oral desmopressin
or imipramine
bedwetting - desmopressin vs imipramine
desmopressin is proffered because of the latter’s adverse effects
substance that affect delta waves
alcohol, benzodiazepines and barbiturates –> decrease delta wave sleep
substance that affect REM
alcohol, benzodiazepines, barbiturates and norepinephrine –> decreased REM sleep
awake to sleep - stages
- awake with eyes open
- awake with eyes closed
- Non-REM
- REM
stages of Non-REM sleep
stage N1
stage N2
stage N3
stage of sleep - proportions
Non-REM stage N1 - 5%
Non-REM stage N2 - 45%
Non-REM stage N3 - 25%
REM - 25%
sleep cycle - EEG waveform during awake open eyes
Beta (highest frequency, lowest amplitude)
sleep cycle - EEG waveform during awake closed eyes
Alpha
sleep cycle - EEG waveform during Non-REM sleep stage N1
theta