CNS neurotransmitters Flashcards
CNS neurotransmitters - types
- Norepinephrine 2. Dopamine 3. 5-HT
4. ach 5. GABA
norepinephrine - change in disease
increased in anxiety
decreased in depression
norepinephrine - location of synthesis in CNS
Locus ceruleus (pons)
Dopomine - change in disease
increased in Huntington
decreased in Parkinson
decreased in depression
increased in Schizophrenia
Dopamine - location of synthesis in CNS
ventral tegmentum AND substantia nigra pars compacta (midbrain)
5-HT - change in disease
Decreased in anxiety
decreased in depression
INCREASED IN PARKINSON
5-HT - location of synthesis
Raphe nuclei (pons, medulla, midbrain)
ACH - change in diseases
increased in Parkinson
decreased in Alzheimer
decreased in Huntington
ACH - location of synthesis in CNS
Basal nucleus of Meynert
GABA - change in disease
decreased in anxiety
decreased in Huntington
GABA -location of synthesis in CNS
Nucleus accumbens
Locus ceruleus synthesize … and is responsible for
norepinephrine
stress and panic
reward center consits of
Nucleus accumbens and septal nucleus
reward center is responsible for
pleasure, fear, addiction
substances that stimulate reward center (and action)
endocannabinoids –> increase desire for high-fat foods
anxiety - changes in neurotransmitters
increased norepinephrine
decreased 5-HT and GABA
depression - changes in neurotransmitters
decreased norepinephrine, dopamine and 5-HT
Huntington disease -changes in neurotransmitters
decreased GABA, ACH
increased dopamine
Parkinson disease - changes in neurotransmitters
decreased dopamine
increased ACH
INCREASED SERETONIN
Alzheimer disease - changes in neurotransmitters
decreased ACH
increased glutamate
locus coeruleus is a …. (area and function)
nucleus in the pons involved with physiological responses to stress and panic.
(υπομέλαν τόπος)
Schizophrenia - changes in neurotransmitters
increased dopamine
CNS neurotransmitters - types and location of synthesis
- Norepinephrine –> Locus ceruleus
- Dopamine –> Ventral tegmentum, substantia nigra pars compacta (midbrain)
- 5-HT –> Raphe nucleis
- ach –> Basal nucleus of Meynert
- GABA –> Nucleus accumbens