acute inflammatory demyelinating polyradiculopathy / Multiple sclerosis Flashcards
Most common subtype of Guillain-Barre syndrome
acute inflammatory demyelinating polyradiculopathy
acute inflammatory demyelinating polyradiculopathy - pathophysiology
Autoimmune condition that destroys Schwann cells –> inflammation and demyelination of peripheral nerves and motor fibers
acute inflammatory demyelinating polyradiculopathy - result in (symptoms)
- symmetric/paralysis (beginning in lower extremities)
- facial paralysis (in 50%)
- autonomic regulation (eg. cardiac irregulation, hypertension, hypertension)
- sensory abnormalities
acute inflammatory demyelinating polyradiculopathy - symetric paralysis course / face??
- beginning in lower extremities
- facial paralysis in 50%
acute inflammatory demyelinating polyradiculopathy - except paralysis, it can cause
- autonomic regulation (eg. cardiac irregulation, hypertension, hypertension)
- sensory abnormalities
acute inflammatory demyelinating polyradiculopathy - course of disease
almost all patients survive
the majority recover completely after weeks or months
acute inflammatory demyelinating polyradiculopathy - lab
increased CSF protein with normal cell count (albuminocytologic dissociation)
acute inflammatory demyelinating polyradiculopathy - increased protein in CSF can cause
papilledema
acute inflammatory demyelinating polyradiculopathy - treatment
- Respiratory support (critical until recovery)
- plasmapheresis
- IV immunoglobins
NO ROLE FOR STEROIDS
acute inflammatory demyelinating polyradiculopathy - associated with (it can be caused by …)
infection:
1. Campylobacter jejuni
2. viral
acute inflammatory demyelinating polyradiculopathy - caused by infection (mechanims)
autoimmune attack of peripheral myelin due to molecular mimicry, inoculations, and stress, but not definitive link to pathogens
Multiple sclerosis - definition
Autoimmune inflammation and demyelination of CNS (brain and spinal cord)
Multiple sclerosis epidemiology - MC in
women, 20-30 years old, whites living further from equator
Multiple sclerosis - patients can present with
- optic neuritis (sudden onset of vision resulting in Marcus Gunn pupils)
- intrenuclear ophthalmoplegia
- hemiparesis
- hemisensory symptoms
- bladder/bowel incontinence
- intention tremor
Multiple sclerosis - Coarse of symptoms
relapsing and remitting
Multiple sclerosis - Charcot classic triad
MNEMONIC –> SIN
- Scanning speech (dysarthria)
- Intention tremor (also Internuclear opthalmoplegia and Incontinence)
- Nystagmus
Multiple sclerosis - gold standard
MRI
Multiple sclerosis - findings in CSF
increased IgG + myelin basic protein
Multiple sclerosis - … are diagnostic
oligoclonal bands