Sex And Reproduction 💘 Flashcards
Stages of sex- arousal/ excitement
Raised bp pulse respiratory rate flushing nipple erect ion genital and pelvic vascular engorgement
Vagina lubrication vasocongestion of vaginal walls erection of clitoris and labia
Scrotum thickens and testes rise
Plateau
Period of excitement prior to orgasm
Increased hr bp muscle tension etc
Sense of impending orgasm can last up to three minutes
Females orgasmic platform, bartholin secretions
Makes urethral sphincter contracts to prevent urine mixing with Semen and retrograde ejaculation pre ejaculatory fluid (cowpers gland)
Orgasm
Conclusion of plateau release of sexual tension and endorphins quick cycles of muscle contractions euphoric sensation
Peak pr bp reap flush etc
Females 5-12 muscle contractions and increased vaginal secretions
Male ejaculate 3-6 contractions of muscles
Resolution
Relaxation make have compulsory refractory period
Pr bp falls drowsiness
Females blood vessels dilate pelvic organs drain cervix opens sand drops into vagina
Makes everything relaxes and testes drop
Effects of aging
Delayed erections less firm longer excitement stage more stimulation needed less ejaculation with less semen
Females reduced lubrications and muscle tension and libido may need hrt
Hypoactive
Sexual desire
Lifelong generalized is never having desire
Situational is no sexual interest in ur partner but want sexual stimulation
Acquired generalized is previously having sexual interest but not don’t
Vaginismus
Can’t achieve penetration due to muscle spasm
May be due to abuse anxiety pain and phobia
Need vagina trainers
Female anorgasmia
Delay/ abscence of orgasm
Unmet needs poor technique can be normal for them
Premature ejaculation
Performance anxiety
Usually younger men
Psychological and drug treatment
Erectile dysfunction
Due to drugs alcohol hiv etc
Treated with injections pellets prostheses pumps psychological pherapy
Make orgasmic disorder
Delay/ abscence of ejaculation sexual trauma hostility lack of trust
Psychological management
Gene that gives male characteristics
SRY box/gene
Gonad formation
Form from potential primordia and form either side of dorsal aorta Form from somatic tissue genital ridge primordia
These cells produce chemoattractant primordial germ cells from the allontois
PGCs migrate along hindgut and populate femoral ridge by week 6
Two mesenchymal knots at either side of aorta
Most pgcs at developing kidney region by day 30
Coelemic epithelia migrate as columns- primitive sex cords
Gonad differentiation
I’m males pgcs colonize medulla in females the cortex
So medulla develops into a testis and cortex degenerates in males
and in females the cortex develops into an ovary and medulla degenerates
Male and female cell differences
Males form leydig cells vascular tissue and myoid cells from which tubule of rete blastema and rete testis
Females form theca cells and vascular tissue
None of the cells in both sexes express sry
Mesonephric primordia
Pgcs in the sexes
Males : pgcs encase in sex cords and cease mitosis
Females : surrounded by granulosa and enter meiosis forming oocytes
Amh and androgen essential for male development
The ducts
Males wolffian duct develops into epididymis vas deferens and c and Müllerian ducts degenerate
In female Müllerian ducts develop into oviducts and uterus and wolffian duct degenerates
Turners syndrome
Unpaired X chromosome
has ovaries but infertile
Woman
Klinfelters syndrome
Extra sec chromosome
Xxy
Has testes but infertile
Man
Androgen insensitivity syndrome
Androgen secrets but no androgen receptors
Xy but phenotypically female and infertile
No internal genitalia testes present testosterone produced
However some become phenotypically male at puberty
Clitoris expands into penis and testes descend so function as normal males
As sometimes rising androgen levels can overcome tissue insensitivity
Congenital adrenal hyperplasia
Xx fetal adrenals hyperactive yo overcome low production of corticosteroids
Both sec ducts retained so external male genitalia
Sry chain
SRY SOX9 inhibits fox12 PGD2->FGF9 AMH SOX 9 is a transcription factor absence results in person having both ovaries and testes ovotestis
FOX12 becomes
Wnt4
Granulosa cell
First mitotic stage of oogenesis
Diplotene into germinal vesicles
They then reside as primary oocytes in the primary follicle and are surrounded by granulosa cells
Folliculogenesis
Starts with primordial follicle which is a primary oocyte surrounded by single layer of granulosa cells and has supporting mesenchymal cells and surrounded by membrane propria
Takes 70+ days to become primary follicle and wiki have zona pellucida
Then preantral with multiple layers of granulosa
Then early Antral which has antral cavity
The mature follicle