Drug Absorption💘 Flashcards
Pharmacokinetics
Factors that determine the journey of the drug through the body
Absorption
The accumulation of a drug in a body compartment
Distribution
Way in which a drug reached each organ of the body
Xenobiotics
Chemical compound foreign to a given biological system
Adme
Absorption distribution and metabolism and excretion
Describes the disposition of a pharmaceutical compound within an organism
Slow absorption reduces
Max concentration but longer duration of action
Most drugs are
Weak acids or bases the stronger the acid bede the harder it is to absorb them
Therapeutic drug monitoring
Focuses on plasma concentration
Relates to extracellular fluid around cells and uses target concentration strategy eg digoxin
Volume of distribution
The volume the drug would occupy to provide the same concentration that is currently in the blood plasma
If high it can easily move out of plasma eg morphine
Peptic ulcers
Caused my stomach acid damaging stomach or duodenum mucosal lining
Can also be due to bacterial infection or aspirin
The urease induced inflammation
Causes pain in abdomen neck back etc bleeding indigestion no appetite and vomiting
NSAIDS
Anti inflammatory- stops cox from making prosta glandins
Analgesic prevents prostaglandins which sensitise spinal neurons to pain
Antipyretic reduces fever, prosta glandins secrete e2 causing increased firing rate of neurons to hypothalamus so now decreased firing
Adverse effects of NSAID
Housekeeping COX inhibited
Abdominal discomfort due to increased gastric acid secretion
Stomach and duodenal ulceration as no mucus to protect lining
Myocardial infarction cox expressed in cells lining blood vessels, inhibition causes blood clotting and high bp
NO saids
Nitric oxide donating
Have gastroprotectibe effect and increased anti inflammatory activity
Aspirin
Only NSAID to irreversibly inactivate both forms of COX enzymes
Anti histamine
Histamine causes reddening wheels and flare
Can be sedating (promethacine)
Or non sedating (cetinizine)
