Rhinovirus Flashcards
the rhinovirus causes
the common cold
there are more than ______ viruses that cause the common cold
200
young children average how many colds per year?
adults?
6-8
2-4
how many cases of the common cold are in the US per year?
62 million cases
how many stereotypes are there for rhinovirus?
and what does this mean?
over 115 distance stereotypes
repeated infections! hard to come up with a vaccine
rhinovirus is part of the
picornavirus family
rhinovirus
ss plus strand RNA
non-enveloped
rhinovirus replication
APUMAR
ICAM-1
intercellular adhesion molecule-1
expressed on epithelial cells, endothelial cells and fibroblasts
binds to canyon
ICAM-1 binding initiates
uncoating
experimental drug to inhibit binding
prevent ICAM-1 from binding in the pocket in capsid
involves VP4
competitive inhibition
Rhinovirus transmission
aerosols and fomites
infectious dose of rhinovirus
as low as 1 virus particle
major mode of transmission of rhinovirus
person to person via hands
how long can rhinovirus survive outside of the human body
48 hours
symptoms of rhinovirus compared to influenza and covid-19
common cold - sore throat and sneezing; NO chills or fever
influenza - NO sore throat or sneezing
Covid-19: NO sneezing
who is at higher risk for rhinovirus
infants and young children
immunocompromised
season for rhinovirus
early autumn through late spring
treating the common cold
rest
fluids
clean humidifier
avoid smoking/pollutants
take non-aspirin pain reliever
saline nasal spray/drops
can sleep protect against the common cold?
YES!
so get some sleep ladies!
common cold includes
rhinoviruses
parainfluenza virus
respiratory syncytial virus (RSV)
COVID
