Chapter 5 - T cell (Exam 3)

Question 1

similarities of antibodies to TCR

Answer 1

both have 2 chains
1 constant region
gene rearrangment

Question 2

differences of antibodies to TCR

Answer 2

Ab is wide range, TCR is peptides only
no further change in TCR after Ag stimulation
Ab has 2 binding sites, TCR has 1
TCR is membrane bound only

Question 3

unlike antibodies, TCR is membrane bound only. This means its function is to only _____________ and it has no ____________

Answer 3

recognize the antigen

no effector function

Question 4

TCR resembles _______ of an antibody

Answer 4

Fab

Question 5

somatic recombination in TCR

Answer 5

rearrange the beta chain
only 1 Ca gene segment

Question 6

RAG proteins are essential for

Answer 6

adaptive immunity

Question 7

omenn syndrome

Answer 7

partial loss of RAG protein activity
fatal

Question 8

treatment for SCID and Omenn syndrome

Answer 8

bone marrow transplant at birth