Rheumatoid and Anti-inflammatory Drugs

Question 1

What drug inhibits the secondary stimulation of the APC to the T-Helper Cell, by binding to the B7 protein - blocking the CD28 activation?

Answer 1

Abatacept

Question 2

What drug blocks RANKL by mimicking PGE?

Answer 2

Densosumab

Question 3

What drug inhibits the activation of B-cells by CD20 protein which inhibits Ca2+ influx into the cell?

Answer 3

Rituximab

Question 4

Name 3 anti-TNF alphas

Answer 4

Etanercept

Infliximab

Adalimumab

Question 5

What drug blocks IL-1?

Answer 5

Anakinra

Question 6

What drug blocks IL-6?

Answer 6

Tocilizumab

Question 7

What is the outcome of blocking COX through NSAIDs that produces the therapeutic effect?

Answer 7

Prostagladins

Question 8

What is the mechanism of action of Aspirin?

Answer 8

permanently binds to Serine residue on COX-1 inhibiting Thromboxane A2 and prostagladins

Question 9

What is the mechanism of action for Glucocorticoids?

Answer 9

1. Remove Heat shock protein 560-90.
   - dimerise with GR protein.

which then enters the nucleus and transcribes for anti-inflammatory [Annexin-1]

2. Blocks the NFkB pathway - inhibiting pro-inflammatory cytokines