Cell Cycle Flashcards
What does the RB protein bind to and inhibit?
Transcription Factor E2F
Inhibits transcription of cell proliferation genes
What Cyclin and CDK complex initiates the cell cycle?
Cylins D
Cyclin Dependent complex 4/6
What Cyclin and CDK complex is released during S phase
Cyclin E
Cyclin Dependent complex 2
What Cyclin and CDK complex is released at the beginning of M-phase. What is this complex also called?
Cyclin B
CDK - 1
Maturation Promoting Factor
What cyclin is released during G2? and what is the CDK complex?
Clylin A
CDK - 2
What is it called when the cell is in G0?
Quiescent Stage
Through the Muturation promoting factor (CDK-1) what will be phosphorlated?
Lamins of nuclear envelope
Histones - condensation of chromotid
Microtubules associated Proteins
What are the checkpoints during the cell cycle?
G1 Check point
G1S Check point
G2M Check point
M Checkpoint
What are proto-onco genes?
Genes that are used to code for proteins or that initiate the cell to enter the cell cycle and divide.
What are onco genes?
Mutated proto-onco genes that code for continual division of the cell.
Give an example of a juxtacrine ligand.
Adjacent cell growth. example. NOTCH
Give an example of a paracrine ligand.
Near by effect. Sonic Hedgehog
What are some characteristics of secondary messenger systems and give an example.
Low concentration in resting cell
Increased proportionally to strength of signal
Produce protional cellular response
example: cAMP
Define Differentiation
The process by which unspecialised cells develop specialised structure or function giving it different characteristics, specific for a type of tissue.
What controls differentiation?
Methylastion
Feed back mechanisms
