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Medicine > Histology > Flashcards

Histology Flashcards

1
Q

What processes are included in tissue processing? and examples

A

Fixation - formaldehyde
Embedding - Wax
Sectioning - cutting
Staining Hhaematoxylin and Eosin

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2
Q

Composition of membrane?

A

50% Proteins
47% Lipids
3% Carbohydrates

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3
Q

Type of Phospholipid found on the outer layer of the membrane?

A

Phosphotidly Choline

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4
Q

Two types of Phospholipids found on the inner layer of the membrane?

A

Phosphotidly Serine

Phosphotidlinistol

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5
Q

What are the two major components of connective tissue?

A

Cellular and Extracellular

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6
Q

What is the TWO main components of the ECM made up of? with examples.

A

Ground Substance - Proteoglycans, GAGs, Glycoproteins, water

Fibres - Collagen, Elastin

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7
Q

What is the main function of the ECM?

A
  1. Structure and Mechanical support
  2. Tensile strength
  3. Creates Micro-environment
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8
Q

What is the main function of Collagen?

A

Tensile Strength

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9
Q

Where would you find Type III Collagen?

A

granulation tissue. Dermis of skin

First collagen laid down in tendon healing

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10
Q

Where would you find Type I Collagen?

A

Dermis of skin, Bone.

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11
Q

Where would you find type II Collagen?

A

Cartilage

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12
Q

Where would you find Collagen type IV?

A

Basement membrane

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13
Q

What is the main function of ground substance?

A

Resist compression

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14
Q

How does ground substance draw water into it?

A

through the very negatively charged GAGs

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15
Q

Where would you find Hyaluronic Acid?

A

Synovial Fluid

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16
Q

Where would you find Chondriotin Sulfate?

A

Cartilage

17
Q

What is the function of the Basement Membrane?

A

Provide support

Attachment to the connective tissue

control of nutrients and signals to the epithelial cells

act as barrier for neoplastic epithelial tissue.

18
Q

What are the main layers of the basement membrane?

A

Lamina Lucida
Lamina Densa
Lamina Fibrorecticularis

19
Q

In arteries where would you find the most abduntant nervous supply?

A

Tunica Media

20
Q

What kind of junctions does the tunica intima of vessels have?

A

Tight Junctions

21
Q

What is the function of the ECM?

A

Anchors cells

Provides pathway for migrating cells

Sequesters growth factors

Provides residence for roaming macrophages

Stem cell occupation and maintains stem environment

22
Q

What is the protein assembly of elastin?

A

Scaffold cross linked fibres

23
Q

In good-pastures syndrome, what occurs?

A

auto - Antibodies destroy collagen IV in the basement membrane of the glomerulus and lungs

24
Q

What collagen is found in fibrocartilage?

A

Type I and II

25
Q

What is Hematoxylin?

A

It is a base and therefore binds to basophilic structures. these are usually acidic. i.e. the nucleus

Medicine (33 decks)

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