Cervical Carcinoma Flashcards
What are the two histological layers of the Cervical?
Endocervical (Cervical canal) - Simple Columnar Cells with glands and mucus
Exocervical - Stratified squamous non-ketratonized cells.
What is the junction of the Endocervical and Exocervical?
Cervical Transitional Zone
Where is the most likely place for Cervical Neoplastics to develop?
On the Cervical Transitional Zone
What are the main causes of Cervical neoplasms?
HPVs
What are the low risk HPV?
6,11
What are the high risk HPV?
16,18
If an individual has HPV 6,11, what is the likely outcome?
Condyloma
If an individual has HPV 16,18 what are the two outcomes?
Cervical Intraepithelial Neoplasia
If an individual has only their basal layer of the squamous epithelial cells, classification of CIN do they have? and is this low or high risk?
CIN -1. Low risk
What cell type is most likely to become dysplasic?
Squamous Epithelial cells
What are the risk factors for Cervical Cancer?
Multiple sexual Partners Male partners who have had multiple partners Oral contraceptive Young age of intercourse Immunosuppression - HIV patients Smoking
What proteins are expressed by the HPV 16,18 and what do they do?
Proteins:
E6: inhibits p53
E7: inhibits RB
What is the name given to morphological change in the cervical epithelial cells nucleus?
Dyskaryotic
What are the cytological morphological changes are seen in Dyskaryotic cells?
Multinucleus
Condensed chromatid
Irregular chromatid
enlargement of nucleus
Why does a cytological study need to be done after a smear test?
Because the cells are disorganised and spread and the architectural structure lost, making CIN levels unable to be seen.
