Respiratory Flashcards
What is a contraindication for having a single lung transpant
Cystic fibrosis
Due to colonisation of infection
What is has good short term survival for SLTx but better long term outcomes for BSLTx
Idiopathic pulmonary fibrosis
Mortality for lung transplant
6-9 years
What is the upper limit of weight for lung transplantation
BMI 30
What are the pros vs cons of tacro vs cyclosporine
Tacro has lower rates of rejection
Tacro has higher rates of diabetes mellitus
Cyclosplorin has higher rates of hypertension
Tacro dose aims post transplant
0-6 mo - 10 to 12
6-12 mo - 8-10
12 mo onwards - 5-8
M-Tor inhibitors main side effect
Impaired wound healing
Basiliximab MOA
CD25 inhibiting monoclonal antibody - surface receptor on T cells
Calcineurin inhibitor sparing
PJP assays
PCR
Beta-D-glucan assay
Diagnosis of PJP and treamtnet
Clinical suspicion but can also do sputum/BAL/biopsy
Full dose bactrim
Clinda + primaquine, IV pentamadine
Aside from PJP, what else does bactrim prophylax against
Toxoplasmosis
Window of best lung function post lung transplant
9-12 months
Purpose of azithromycin 3 times a week for acute cellular rejection
Immunomodulatory proporties
What is an immunological marker on histology for antibody mediated rejection
Cd4 staining (for complement pathway)
What are the factors that determine staging of antibody mediated rejection
Circulating DSAs
C4d+ staining no graft dysfuncton or capillary injury
(see slides)
