Immunology allergy Alfred Lecture Flashcards
Type III hypersensitivity
Immune complex hypersensitivity
e.g. acute vasculitis, renal lesions in systemic lupus erythematour, farmer’s lung, serum sickness
MOA of Immediate hypersensitivity
antigen is presented to the patient. The APC presents it to the TH2 lymphocyte. The B cell produces antigen specific IgE which causes binding of IgE to mast cells
On subsequent exposure, the mast cell degraulates
Difference between sensitization and allergy
allergy is IgE following allergen exposure + symptoms
sensitization may not produce symptoms
Type I hypersensitivity - IgE levels
associated with elevated IgE levels
most common trigger of food dependent exercise induced anaphylaxis
wheat 57%
oral allergy syndrome
- cross reactivity between pollen and fruits
- causes mild oral itch/tingling
gold standard for diagnosis of food allergy
food challenge
Management of anaphylaxis on beta blockers
glucagon - vasopressor effects that’s not beta-dependent
early intervention in paediatric group for reducing peanut allergy
early introduction of peanuts 4-6 months
MOA of specific immunotherapy
decrease allergen speciic IgE
Increase IL-10
Increase Treg
Decreased Th2
what is delayed hypersensitivity allergy reaction mediated by?
T cells
MOA of steven johnson syndrome
type IV
T-cell mediated
Management of penicillin allergy in need of penicillin (e.g. IE or syphillis)
rapid desensitisation protocol
anaphylactoid reaction triggers
radiocontrast, vancomycin, opiates, N-acetyl cysteine
MOA anaphylactoid drug reactions
no specific IgE
direct mast cell degranulation
