Geriatrics

Question 1

Biggest cause of death in women

Answer 1

Dementia

Question 2

FRAIL mnemonic

Answer 2

Fatigability
Resistance
Ambulation
Illness
Loss of weight

Question 3

Dementia diagnosis

Answer 3

o Impairment of memory and AT LEAST 1 other cognitive domain – aphasia, apraxiam agnosia, executive function (planning, organizing, abstracting)

Significant decline in social occupation function

Exclude delirium and active psychiatric disease

Question 4

4 domains in CAM delirium screening

Answer 4

Inattention
Acute onset
Disorganised thinking
Altered level of consciousness

Question 5

Strongest predictor of future fall

Answer 5

Past fall

Question 6

Pathophysiological features of Lewy Body Dementia

Answer 6

Lewy bodies - that stain positively for ubiquitin and alpha-synuclein

Question 7

Essential neuropathologic changes of AD

Answer 7

Neurofibrillary degeneration + amyloid

Question 8

Pathogenesis of AD

Answer 8

Decreased clearance of amyloid beta peptides + hyperphosphorylation of tau leading to neurofibrillary tangles

Question 9

Adverse effects of PPIs

Answer 9

Hypomagnesium
Bone fragility
C. Diff infection
?Pneumonia
?Increased mortality

Question 10

Alzheimer’s disease CSF beta-amyloid levels

Answer 10

low because they deposit into the grey matter

Question 11

APOE chromosome

Answer 11

19

Question 12

Beta-amyloid gene chromosome

Answer 12

21

Question 13

what cognitive screening tool is best for picking up MCI

Answer 13

MOCA

Question 14

What chromosome is the tau protein gene on?

Answer 14

17