MJA reviews

Question 1

Risk factors for thrombosis in antiphospholipid syndrome

Answer 1

• lupus anticoagulant or antibodies against β2-glycoprotein 1 occurring alone (higher risk of thrombosis than with anticar- diolipin alone)
• high antibody titres (particularly IgG)
• positivity for multiple antibodies (associated with the highest risk of thrombosis)
• additional risk factors for thrombosis at the time of diagnosis (eg, hypertension, smoking and diabetes mellitus for arterial thrombosis, and hyperlipidaemia for venous thrombosis).

Question 2

Primary prophylaxis for APS associated with SLE

Answer 2

hydroxychloroquine

Question 3

Propimary prophylaxis for APS with high risk profile without SLE

Answer 3

Low dose aspirin - weak recommendation