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FRACP Shuyu > Kinase inhibitors > Flashcards

Kinase inhibitors Flashcards

1
Q

Abemaciclib

A

CDK4/6 inhibitor - breast cancer

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2
Q

Acalabrutinib

A

Bruton’s tyrosine kinase

Used in CLL, SLL, mantle cell lymphoma

ADR - AF/aflutter, transient lymphocytosis, increased bleeding from platelet dysfunction

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3
Q

Afatinib

A

EGFR, HER2, HER4 receptor inhibitor

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4
Q

Alectinib

A

ALK receptor

For ALK-positive NSCLC

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5
Q

Axitinib

A

VEGF receptor inhibitor

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6
Q

Baricitinib

A

JAK 1 and JAK2 inhibitor

Used for RA, atopic dermatitis, COVID
Do not use in severe renal impairment

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7
Q

Binimetinib

A

Mitogen-activated extracellular kinases (MEK) 1 + 2

Used in melanoma

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8
Q

Brigatinib

A

ALK receptor, ROS1

NSCLC

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9
Q

Carbozatinib

A

Hepatocyte growth factor receptor (HGFR, c-Met), VEGFR type 2, AXL

Used in HCC and advanced RCC

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10
Q

Ceritinib

A

ALK receptor

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11
Q

Cobimetinib

A

MEK1, MEK2

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12
Q

Crizotinib

A

ALK receptor, c-Met, ROS1

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13
Q

Dabrafinib

A

BRAF including V600E and V600K

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14
Q

Dasatinib

A

BCR-ABL1, Src family, stem cell factor receptor, PDGFR

Used in CML, phil chromosome positive ALL

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15
Q

Encorafenib

A

BRAF inhibitor

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16
Q

Entrectinib

A

Tropomysin receptor tyrosine kinase, ROS1, ALK receptor

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17
Q

Erlotinib

A

EGFR

Used in NSCLC, pancreatic Ca

18
Q

Gefitinib

A

EGFR

19
Q

Ibrutinib

A

BTK

Used for CLL, SLL, mantle cell lymphoma, Waldenstrom macoglobulinaemia

20
Q

Idelalisib

A

PI3K inhibitor

21
Q

Imatinib

A

BCR-ABL1, c-Kit, PDGFR

Used in CML, GIST, phil chromosome positive ALL, MDS

22
Q

Lapatinib

A

EGFR, HER2

23
Q

Lenvatinib

A

VEGFR types 1-3, fibroblast growth factor types 1-4, PDGFR, c-Kit, RET

24
Q

Lorlatinib

A

ALK receptor, ROS1

25
Q

Midostaurin

A

VEGFR type 2, PDGFR, c-Kit, FLT-3, protein kinase C

Used in AML, advanced systemic mastocytosis

26
Q

Nilotinib

A

BCR-ABL1, c-Kit, ephrin receptor, PDGFR

Used in CML

27
Q

Nintedanib

A

VEGFR types 1-3, PDGFR, FGFR types 1-3

Used in IPF

28
Q

Osimertinib

A

EGFR including T790M mutation

Used in NSCLC

29
Q

Palbociclib

A

CDK4/6 inhibtor

30
Q

Pazopanib

A

VEGFR types 1-3, PDGFR, c-Kit

31
Q

Ponatinib

A

BCR-ABL1, c-Kit, PLT-3, RET

32
Q

Regorafenib

A

VEGFR types 1-3, PDGFR, c-Kit, RET

33
Q

Ribociclib

A

CDK4/6 inhibitor

Used in advanced or metastatic breast cancer

34
Q

Ruxolitinib

A

JAK 1, JAK2

Used in myelofibrosis, PCV

35
Q

Sorafenib

A

VEGFR types 2-3, PDGFR, c-Kit, FLT-3

Used in RCC, HCC, thyroid carcinoma

36
Q

Sunitinib

A

VEGFR types 1-3, PDGFR, c-Kit, FLT-3

37
Q

Tofacitinib

A

JAK1, JAK2, JAK3

38
Q

Trametinib

A

MEK1, MEK2

39
Q

Upadacitinib

A

JAK1

Used in RA, psoriatic arthritis, ankylosing spondylitis

40
Q

Vandetanib

A

VEGFR types 2-3, EGFR, RET

41
Q

Vemurafenib

A

BRAF V600E and V600K

Used in metastatic melanoma with BRAF V600E mutation

FRACP Shuyu (65 decks)

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