Dermatology Flashcards

1
Q

BRAF inhibitor monotherapy vs combination with MEK inhibitor skin effects

A

combination has decreased incidence of BRAF inhibitor induced cutaneous AEs

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2
Q

BRAF tender red purplr papules and nodules with fever and neuropenia dx

A

Sweet’s syndrome

tx with steroids

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3
Q

MEK inhibitor rash

A

most common papulopustular eruptions

similar to EGFR inhbitors
dose dependent

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4
Q

management of anti-PD-1 autoimmune blistering

A

IVIG +/- steroids

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5
Q

extensive blisters over trunk and all limbs but sparing face and mucous
direct immunoflurescence on biopsy of perilesional skin shows a linear deposition ofimmunoglobulin G and complement 3 at epidermal basement membrane line dx

A

bullous pemphigoid

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6
Q

management of bullous pemphigoid

A
topic steroids
oral steroids
aza
mycophenolate
IVIG
other immunosuppressants
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7
Q

treatment of cryoglobulinaemia

A

treat hep C

interferon alpha and ribavirin

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8
Q

herpetiformis dermatitis complications

A

lymphoma, spleen atrophy

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9
Q

herpetiformis dermatitis tx

A

stop gluten

dapson

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10
Q

mycosis fungoides clinical appearance

A

atrophic skin on buttock, breast, girdle, horseshoe appearance

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11
Q

pityriasis rosea clinical appearance

A

herald patch 80% - starts as 1 spot that grows
christmas tree pattern
self limiting

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12
Q

erythema migrans cause

A

lyme disease borrelia burgdorferi

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13
Q

bilicated papule diagnosis

A

musculum contagiosum

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14
Q

target lesions rash dx

A

erythema multiforme

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15
Q

erythema multiforme most common cause

A

HSV

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16
Q

Koebner’s phenomenon

A

trauma to the skin causes rash to appear at the site of injury

e.g. vitiligo, psoariasis, lichen planus

17
Q

treatment of TENS

A

High dose pred / cyclosporine

etanecept next step

No survival benefit in IVIG

transfer to burns tertiary unit