Alfred 2017 Exam Flashcards
5 Lacunar Syndromes
- Pure motor hemiparesis
- Unilateral paralysis of arm, face, leg
- Dysarhthria, dysphagia - Pure sensory syndrome
- Unilateral numbness of face, leg, arm - Ataxis hemiparesis
- Unilateral weakness and limb ataxia - Sensorimotor syndrome
- Hemiparesis or hemiplegia of face, arm and leg
- Ipsilateral sensory impairment - Dysarthria-clumsy hand syndrome
- Unilateral facial weakness
- Dysarthria + dysphagia
- Mild hand weakness and clumsiness
What condition is CGRP antibodies associated with
Trigeminal neuralgia
What type of headache is botulinum toxin type A useful for
Chronic migraine (16-30 headache days a month)
Do statin-induced myopathies resolve after cessation of statin
Symptoms should resolve within weeks
If it doesn’t consider immune-mediated necrotising myopathy
What antibodies mediated immune-mediated necrotising myopathy
HMG-CoA reductase antibodies
What is the nature of symptoms in statin-associated myopathy
Bilateral
Large muscle groups
Symptom onset 4-6 weeks after statin initiation
Where are lesions associated with hemiballism located
Subthalamic nucleus
What tumours are associated with RET gain of function mutation
MEN 2A MEN 2B
Medullary thyroid cancer
Phaeochromocytoma
Parathyroid hyperplasia
Ivabradine MOA
Blocks funny channel to prevent sodium influx - reduces action potential
What causes the systolic murmur in ASD
Increased flow from RV across pulmonary valve to pulmonary arteries
P2Y12 inhibitors onset of effect and reversibility
Clopidogrel
- 4 hours, irreversible
Ticagrelor
- 30 mins, reversible
Prasugrel
- 30 mins, irreversible
What medication increases AUC of dabigatran
Verapamil
Morphine to codeine conversion
1:10
Oral morphine 1mg = oral codeine 10mg
Morphine to hydromorphone conversion
5:1
Morphine 5mg = hydromorphone 1mg
Morphine to oxycodone conversion
1.5:1
Oral morphine 15mg = oral oxycodone 10mg
Morphine to tapentadol
1:3
oral morphine 100mg = oral tapentadol 300mg