RESP: ANTIHISTAMINES Flashcards

1
Q

ANTIHISTAMINES: INDICATIONS

A
  • 1st line for allergies (hay fever)
  • Aid relief of Pruritis and Hives to insect bites or drug allergies
  • Adjunct in Anaphylaxis
  • Can be used for Nausea and Vomiting
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2
Q

ANTIHISTAMINES: MOA

A

Antagonist of H1 receptor

  • Histamine is released from storage granules in mast cells as a result of antigen binding to IgE on the cell surface
  • Induces type 1 Hypersensitivity
  • AntiH blocks the effects of excessive Histamine release
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3
Q

ANTIHISTAMINES: ADVERSE EFFECTS

A
  • Sedation ( H1 receptors have a role in wakefulness)

- Second gen AntiH don’t have this effect as they don’t cross the BBB

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4
Q

ANTIHISTAMINES: WARNINGS

A
  • Sedating Anti H should be avoided in Liver Dx patients
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5
Q

ANTIHISTAMINES: INTERACTIONS

A
  • NA
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