MSK: AMINOSALICYLATES

Question 1

AMINOSALICYLATES: INDICATIONS

Answer 1

• UC

- RA

Question 2

AMINOSALICYLATES: MOA

Answer 2

• In ulcerative colitis (UC), mesalazine and sulfasalazine both exert their therapeutic effects by releasing 5-aminosalicylic acid (5-ASA), it has both anti-inflammatory and immunosuppressive effects

Question 3

AMINOSALICYLATES: ADVERSE EFFECTS

Answer 3

• GI upset
• HA
• Blood abnormalities = leucopenia, thrombocytopenia and renal impairment
• Men = OLIGOSPERMIA
• Serious Hypersensitivity Rxn = fever, rash, liver abnormality

Question 4

AMINOSALICYLATES: WARNINGS

Answer 4

• Aspiring HS

Question 5

AMINOSALICYLATES: INTERACTIONS

Answer 5

• Mesalazine tablets with a pH-sensitive coating (e.g. Asacol® MR) may interact with drugs that alter gut pH
• For example, proton pump inhibitors increase gastric pH so may cause the coating to be broken down prematurely.
• Lactulose lowers stool pH and may prevent 5-ASA release in the colon

Question 6

AMINOSALICYLATES: EXAMPLES

Answer 6

• Mesalazine

- Sulfasalazine