MSK: QUININE

Question 1

QUININE: INDICATIONS

Answer 1

• Prevent night time cramps

- 1st line for Plasmodium Falciparum -MALARIA

Question 2

QUININE: MOA

Answer 2

• Leg Cramps - reduce the excitability of the motor end plate in response to ACETYLCHOLINE STIMULATION (reduces frequency of muscle contractions)
• Malaria - Rapidly kills P.Falciparum parasites in schizont stage of the blood

Question 3

QUININE: ADVERSE EFFECTS

Answer 3

• v toxic and can be fatal in OD
• Tinnitus, deafness + blindness (which may be permanent)
• GI upset, HS Rxns
• Prolongs the QT interval and causes a predisposition to Arrhythmias
• Hypoglycemia can also occur

Question 4

QUININE: WARNINGS

Answer 4

• Existing hearing/visual loss
• Teratogenic -> should not be prescribed in the 1st trimester
• G6PD deficiency = Precipitate Haemolysis

Question 5

QUININE:INTERACTIONS

Answer 5

• Drugs that prolong the QT interval -> can cause arrhythmias
• Amiodarone, antipsychotics, quinolones, macrolides, SSRIs

Question 6

QUININE: EXAMPLES

Answer 6

• Quinine Sulfate