NERVOUS SYSTEM: GABAPENTIN + PREGABALIN

Question 1

GABAPENTIN + PREGABALIN: INDICATIONS

Answer 1

• Focal epilepsies
• Neuropathic pain
• Migraine prophylaxis
• GAD

Question 2

GABAPENTIN + PREGABALIN: MOA

Answer 2

• It binds with voltage sensitive calcium (Ca2+) channels, where it presumably prevents inflow of Ca2+ and, in so doing, inhibits neurotransmitter release
• This interferes with synaptic transmission and reduces neuronal excitability

Question 3

GABAPENTIN + PREGABALIN: ADVERSE EFFECTS

Answer 3

• Drowsiness
• Dizziness
• Ataxia

Question 4

GABAPENTIN + PREGABALIN: WARNINGS

Answer 4

• Depend on kidneys for their excretion, should dose should be reduced in renal impairment

Question 5

GABAPENTIN + PREGABALIN: IMPORTANT INTERACTIONS

Answer 5

• Sedative effects enhanced by combining with other sedating drugs (benzos)