NEURO: OPIOID COMPOUND PREPARATIONS

Question 1

OPIOID COMPOUND PREPARATIONS: INDICATIONS

Answer 1

• Mild to moderate pain second line agents when simple analgesics such as paracetamol are insufficient

Question 2

OPIOID COMPOUND PREPARATIONS: MOA

Answer 2

Paracetamol = weak inhibitor of COX

Codeine and Dihydrocodeine are weak opioids = agonists of opioid mu receptors

Question 3

OPIOID COMPOUND PREPARATIONS: ADVERSE EFFECTS

Answer 3

• Paracetamol = side effects are rare
• Codeine and dihydrocodeine = nausea, constipation and drowsiness
• In OD, paracetamol = heptatotoxicity
• Opioid Toxicity = neurological and respiratory depression

Question 4

OPIOID COMPOUND PREPARATIONS: WARNINGS

Answer 4

• Significant respiratory Dx
• Reduce doses in cases of renal + hepatic impairment
• Elderly

Question 5

OPIOID COMPOUND PREPARATIONS: INTERACTIONS

Answer 5

• Do not use with other sedating drugs (antipsychotics, benzos and TCAs)

Question 6

OPIOID COMPOUND PREPARATIONS: EXAMPLES

Answer 6

• Co-codamol

- Co- drydamol