MSK: ALLOPURINOL

Question 1

ALLOPURINOL: INDICATIONS

Answer 1

• Gout
• Renal Stones
• Hyperuricemia
• Tumour Lysis Syndrome

Question 2

ALLOPURINOL: MOA

Answer 2

• Xanthine Oxidase Inhibitor

- Lowers plasma uric acid concentrations and decreases precipitation of UA in joints/kidneys

Question 3

ALLOPURINOL: ADVERSE EFFECTS

Answer 3

• Skin rash (can be mild or more serious HSRXN = Steven-Johnson Syndrome, Toxic Epidermal Necrolysis)
• Drug hypersensitivity syndrome = can include fever, eosinophilia, lymphadenopathy and involvement of other organs, such as the liver and skin
• A can also worsen GOUT attacks

Question 4

ALLOPURINOL: WARNINGS

Answer 4

• Acute attacks of Gout
• Recurrent skin rash
• Severe HYPERSENSITIVITY
• Severe renal/liver impairment

Question 5

ALLOPURINOL: INTERACTIONS

Answer 5

• Mercaptopurine and its pro-drug azathioprine
• Co-prescription of allopurinol with amoxicillin
• ACE inhibitors or thiazides