NEURO: Z DRUGS

Question 1

Z DRUGS: INDICATIONS

Answer 1

• Insomnia

Question 2

Z DRUGS: MOA

Answer 2

• Enhances and facilitates the binding of GABA to GABA-A receptor
• Widespread depressive effect on on synaptic transmission

Question 3

Z DRUGS: ADVERSE EFFECTS

Answer 3

• Daytime sleepiness
• Rebound insomnia
• CNS effects = headaches, confusion, nightmares, amnesia
• ZOPLICONE = taste disturbance
• ZOPLIDEM = GI upset
• Prolonges use beyond 4 weeks = dependence, withdrawl symptoms on stopping ( headaches, muscle pains and anxiety)
• OD = drowsiness, coma and respiratory depression

Question 4

Z DRUGS: WARNINGS

Answer 4

• Elderley
• Obstructive sleep apnoea
• Resp muscle weakness
• Resp depression

Question 5

Z DRUGS: INTERACTIONS

Answer 5

• Enhance the effects of alcohol, antihistamines and benzodiazepines
• Enhance hypotensive effects of antihypertensive medications
• P450 drug inhibitors = macroclides enhance sedation
• P450 drug inducers = phenytoin, rifampicin can impair sedation

Question 6

Z DRUGS: EXAMPLES

Answer 6

• Zoplicone

- Zolpidem