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Top 100 Drugs > NEURO: STATINS > Flashcards

NEURO: STATINS Flashcards

1
Q

STATINS: INDICATIONS

A
  • Primary prevention of CVDx
  • Secondary prevention of CVDx
  • Primary Hyperlipidemia
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2
Q

STATINS: MOA

A
  • Reduce serum cholesterol levels

- Inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) reductase

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3
Q

STATINS: ADVERSE EFFECT

A
  • Generally safe and well tolderated
  • Headaches
  • GI disturbances
  • Serious effects on muscle = myopathy, rhabdomyolysis
  • Rise in Liver enzymes
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4
Q

STATINS: WARNINGS

A
  • Used in caution with patients with hepatic impairment
  • Reduce dose in patients with renal impairment
  • Avoid in pregnant and breastfeeding women
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5
Q

STATINS: IMPORTANT INTERACTIONS

A
  • Cytochrome P450 inhibitors = amiodarone, diltiazem, itraconazole, macroclides and protease inhibitors
  • Amlodipine
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6
Q

STATINS: EXAMPLES

A
  • Simvastatin
  • Atorvastatin
  • Pravastatin
  • Rosuvastatin
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Top 100 Drugs (111 decks)

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