CARDIO: ACE INHIBITORS

Question 1

ACE INHIBITORS: INDICATIONS

Answer 1

• HTN
• CHF
• Ischaemic Heart Dx

Question 2

ACE INHIBITORS: MOA

Answer 2

• prevent conversion of ANGIOTENSIN 1->2
• Ang II is a vasoconstrictor and stimulates ALDOSTERONE secretion
• blocking its action reduces PVR and afterload which lower BPS

Question 3

ACE INHIBITORS: ADVERSE EFFECTS

Answer 3

• Hypotension
• Persistent dry cough (increased levels of bradykinin)
• Hyperkalaemia (low levels of aldosterone promotes pottassium retention)
• Worsen renal failure
• Angiodema
• Anaphylactictoid rxns

Question 4

ACE INHIBITORS: WARNINGS

Answer 4

• Renal artery stenosis
• AKI
• Pregnant/breast feeding
• CKD

Question 5

ACE INHIBITORS: INTERACTIONS

Answer 5

• Pottassium elevating drugs and Pottassium supplements/sparing diuretics => increased risk of hyperkalaemia
• NSAID => increased risk of renal failure

Question 6

ACE INHIBITORS: EXAMPLES

Answer 6

• Ramipril
• Lisinopril
• Perindopril