CARDIO: ADRENALINE (EPINEPHRINE)

Question 1

ADRENALINE/EPINEPHRINE: INDICATIONS

Answer 1

-Cardiac arrest
- Anaphylaxis
- Induce local vasoconstriction
EXAMPLE - Control local bleeding, prolong local anaesthesia

Question 2

ADRENALINE/EPINEPHRINE: MOA

Answer 2

• Potent agonist of a1, a2, b1, b2 adrenoreceptors
• Sympathetic effects - vasoconstriction of vessels, supplying the skin, muscosa and abdo viscera (mainly alph 1)
• Increases HR, contraction and myocardial excitability and vessels that supply the heart and muscles (b2)
• Cardiac arrest = redistribution of blood flow in favour of the heart
• B2 receptors = bronchodilatation and suppression of inflammatory mediator release from mast cells

Question 3

ADRENALINE/EPINEPHRINE: ADVERSE EFFECTS

Answer 3

• Adrenaline induced HTN
• In ANAPHYLAXIS patients - anxiety, tremor, headache, palpatations
• Angina, MI, Arrhythmias

Question 4

ADRENALINE/EPINEPHRINE: WARNINGS

Answer 4

No CI in cardiac use or anaphylaxis

• Heart dx patients, use in caution when trying to induce local vasoconstriction
• Areas supplied by end artery such as fingers and toes, poor collateral supply can cause vasoconstriction and tissue necrosis

Question 5

ADRENALINE/EPINEPHRINE: INTERACTIONS

Answer 5

• Beta blocker