CARDIO: COMPOUND SODIUM LACTATE (HARTMANN'S SOLUTION)

Question 1

COMPOUND SODIUM LACTATE (HARTMANN’S SOLUTION): INDICATIONS

Answer 1

• Provide sodium and water through IV

- Expand circulating volume in states of circulatory failure (eg shock) - done as a fluid challenge

Question 2

COMPOUND SODIUM LACTATE (HARTMANN’S SOLUTION): MOA

Answer 2

• Balanced salt solution, with its constituents designed to mimic serum
• In presence of adequate liver fxn - lactate metabolised to PYRUVATE, then to either glucose or carbon dioxide and water
• Release of bicarb in both cases
• Sodium = used to provide sodium and water intravenously and also for the expansion of circulating volume

Question 3

COMPOUND SODIUM LACTATE (HARTMANN’S SOLUTION): ADVERSE EFFECTS

Answer 3

• Excessive administration can cause a fall in CO and severe heart failure by increasing left ventricular filling beyond the point of maximal contractility on the Starling Curve
• Oedema, relevant in patients who have received multiple fluid challenge, since about 80% of the administered volume will be lost into tissue fluid
• NaCL advantage - lower chloride content and less likely to cause hypercholaremic acidosis

Question 4

COMPOUND SODIUM LACTATE (HARTMANN’S SOLUTION): WARNINGS

Answer 4

• Heart Failure
• Renal Impairment
• Severe Liver Dx

Question 5

COMPOUND SODIUM LACTATE (HARTMANN’S SOLUTION): INTERACTIONS

Answer 5

• NONE