OPTOM: PROSTAGLANDIN EYE DROPS

Question 1

PROSTAGLANDIN EYE DROPS: INDICATIONS

Answer 1

• Reduce IOP in open angle glaucoma and ocular HTN

Question 2

PROSTAGLANDIN EYE DROPS: MOA

Answer 2

• Analogues of prostaglandin F2α reduce intraocular pressure by increasing outflow of aqueous humour via the uveoscleral pathway

Question 3

PROSTAGLANDIN EYE DROPS: ADVERSE EFFECTS

Answer 3

• Locally in the eye they may cause blurred vision, conjunctival reddening (hyperaemia), and ocular irritation and pain
• They may also cause a permanent change in eye colour by increasing the amount of melanin in stromal melanocytes of the iris. This affects about one in three patients and is most noticeable when treatment is restricted to one eye

Question 4

PROSTAGLANDIN EYE DROPS: WARNINGS

Answer 4

• lens is absent ( aphakia) or artificial ( pseudophakia); and in patients with or at risk of iritis, uveitis or macular oedema
• In patients with severe asthma there is a theoretical risk of provoking bronchoconstriction,

Question 5

PROSTAGLANDIN EYE DROPS: INTERACTIONS

Answer 5

• NONE

Question 6

PROSTAGLANDIN EYE DROPS: EXAMPLES

Answer 6

• Latanoprost

- Bimatoprost