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VETM 425 > Repro 3 > Flashcards

Repro 3 Flashcards

1
Q

define the following: early embryonic death, abortion, stillbirth, non viable neonate

A

EED: death up to 35-45 days postconception in large animals, 20 days in dogs and cats
abortion: expulsion of the fetus prior to the time of viability
stillbirth: expulsion of a dead fetus at the time of viability
non viable neonate: delivery of a live, weak born animal

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2
Q

is it easy to diagnose something based on fetal loss?

A

NO! reaching a definitive diagnosis is the excpetion, not the rule

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3
Q

fetal loss is a combo of what 3 factors?

A

maternal disease, fetal diease, and placental disease

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4
Q

what makes it easier to diagnose a cause for fetal loss?

A

if there is an outbreak of an infectious agent, if the cause is infectious, if the fetus is fresh, and if the placenta is included

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5
Q

in most species the common known causes of fetal loss are ______, with the exception of?

A

infectious
horses are unique because they have a lage number of non infectious causes of fetal loss

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6
Q

what are some unique features of horses that cause fetal loss?

A

twinning, inadequate villus development, premature placental separation, body pregnancy (not enough placenta to go around), umbillical cord anomalies

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7
Q

list some examples of bacterial, viral, and protozoal causes of fetal loss. which ones are NOT zoonotic?

A

bacteria: brucella, camplyobacter, chlamidyia, leptsospira, listeria, salmonella, NOT ZOONOTIC: mycoplasma, ureaplasma
viruses: herepesviruses and pestiviruses (not zoonotic)
protozoa: toxoplasma gondi, NOT ZOONOTIC: nespora caninium

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8
Q

what will you see in a fetus if it has been infected with a herpesvirus?

A

multifocal small white foci of necrosis commonly in the liver but can be found everywhere, intranuclear inclusion bodies on histo

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9
Q

what would you see in a fetus that has been infected with a pestivirus like BVD or classical swine fever in pigs?

A

fetal death or persistent infection or fetal malformation (often CNS), depending on the virus

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10
Q

this is the liver of a fetus. what do you suspect?

A

infection with a herpesvirus

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11
Q

this is a fetus brain. what could cause this?

A

infection with a pestivures or parvoviruses (cereballar hypoplasia)

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12
Q

what is the most common oute of infection of the placenta in ruminants and in hoses?

A

ruminants: hematogenous spread
horses: asceding infection due to loose cervix

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13
Q

once placentitis is esablished, organisms can do what 3 things?

A
  1. penetrate the aminion and colonize the skin of the fetus
  2. inhale or ingest contaminated amniotic fluid
  3. spread thu umbillical vessels to the liver and hematogenously spread thru fetus
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14
Q

what are your 6 steps in diagnosing fetal loss?

A
  1. exaine the placenta for any abnormalities
  2. external examination of the fetus for evidence of fetal distress, congenial abnormalities, or skin lesions
  3. estimate the gestational age of the fetus
  4. determine the state of preservation at the time of expulsion
  5. determine if it was stillborn or a nonviable neonate
  6. do a routeine necropsy of the fetus
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15
Q

what is this?

A

a normal ruminant placenta

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16
Q

you see this during your examination of a placena. what is this?

A

amniotic plaques, they are foci of squamous epithelial cells and they are NORMAL, incicental finding

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17
Q

this is a cow placenta. what is this showing?

A

adventitial placentation, to compensate for inadequate placentomes, a NORMAL and INCIDENTAL finding (not placentitis)

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18
Q

you find this in a horse placenta. what is it?

A

a hippomane, collection of sediments, completely normal

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19
Q

when you see intercotyledonary and cotyledonary placentitis, consider what

A

bacterial and fungal causes first, esp brucella species, wear gloves!!

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20
Q

this is a bovine placenta. what is shown here?

A

necrotizing intercoyledonary and cotyledonary palcentitis caused by bacillus licheniforms

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21
Q

if you have an exaggerated cotyledonary cupping and a leathery appearance and infarction in a placenta, what should you suspect?

A

mycotic placentitis

22
Q

this is a bovine placenta. what is shown here?

A

mycotic placentitis

23
Q

if you have a cotyledonary placentitis with pinpoint foci of necrosis and mineralization you should think of

A

protozoal infection, esp toxoplasmosis in small ruminants

24
Q

this is a sheep placenta. what do you suspect?

A

a protzoan infection with toxoplasma gondii

25
Q

what is the cervical star in mares? why is it significant?

A

where the fetus should be exiting and there’s no nilli there so there’s also no endometrium there. the horse cervis is loose so placentitis is the most severe adjacent to the cervical star

26
Q

this is a mare placenta. what is shown here near the green star?

A

bacterial placentitis, fibrin, edema, necrotic debris, the green star is the cervical star

27
Q

the umbillical cord should be how long normally? in horses, what can happen if the umbillical cord is longer than this?

A

normally ,83cm, no more than 3-4 twists
long cords are prone to torsion which is a common non infectious cause of equine abortion

28
Q

this is a horse fetus. what likely killed this fetus?

A

umbillical torsion due to long umbillical cord. you can see the congestion and edema

29
Q

what is meconium and why is it important?

A

essentially it is babie’s first poo poo. when a fetus is distrssed from intrauterine hypoxia, meconium is released into the amnion and the fetus gasps/gulps and aspirates/ingests amniotic fluid into the lungs and abomasum respectively

30
Q

what is wrong with this fetus besides the fact that it is dead

A

it has meconium staining on it’s skin, indicating fetal distress

31
Q

this is the trachea of a fetus, what does this tell you?

A

there is meconium in the trachea indicating fetal distress, the fetus has aspirated it into the lungs

32
Q

what can happen if a calf get’s stuck halfway through the birth canal? (dystocia)

A

there will be reduced venous and lymphatic drainage, leading to edema, congestion, and hemorrhage of the head and tongue

33
Q

if you see fetal dermatitis or hyperkeratosis, what does that indicate?

A

a mycotic infection

34
Q

this is a fetus head, what does this tell you?

A

mycotic infection of the fetus skin

35
Q

why do we want to figure out the gestational age of a fetus when looking for a diagnosis?

A

different things kill fetuses at different points in gestaion, for example, neospora caninum will infect and cause abortions in calves mid gestation

36
Q

why do we care about finding out the state of preservation at the time of expulsion of a fetus?

A

can suggest the type of condition

37
Q

describe the difference between a fetus dying suddenly and a fetus dying slowly and how you would be able to see that

A

if a fetus dies suddenly, it doesn’t have time to signal to the cow and they remain in utero to cook for a while, when they are expulsed they are mummified and autolyzed

if a fetus dies slowly, it has time to initiate partution and they are expelled immediately and may be born dead or weak, but they are fresh at the time of expulsion

38
Q

a fresh fetus is typical of what?

A

chronic disease and may be small for it’s age

39
Q

an autolyzed fetus indicates what?

A

rapid fetal death usually from viremia, septicemia, or protozoal infections

40
Q

if a fetus looks like this, what does this tell you about how it died?

A

it autolyzed so it died suddenly, from viremia, septicemia, or protozoal infection

41
Q

if you have a mummified fetus, what does this tell you about how it died?

A

bacteria must be absent, aka no bacterial infections
can be viruses or protozoa still though, or even twinning

42
Q

viruses such as parvo and enterovirus cause what in pigs?

A

stillbirth, mummifcation, embryonic death and infertility (SMEDI)

43
Q

if you have a fetus that is macerated, what does this tell you about how it died?

A

bacterial infection is required for this to happen, so either the bacteria killed the fetus or the cervix was open and there was an ascencding infection

44
Q

how can you tell between a stillborn fetus and a nonviable neonate fetus (aka, how can you tell if it was dead when it was born or if it died shortly after birth)

A

if the lungs are airated, the baby was alive and took a breath so it would be a nonviable neonate and not a stillborn
if there is hemorrhage, this means the baby was alive (dead animals do not bleed), so it would be a nonviable neoante and not a stillborn

45
Q

what can cause goiter in a fetus?

A

iodine deficient diet, goiterogenic substances in the diet, genetic

46
Q

what does it mean if the fetus you’re necropsying has a hemorrhagic tracheal cast? what about a fibrinous tracheal cast?

A

hemorrhagic cast: pathognomonic for trueperella pyogenes abortion in cattle
fibrinous cast: pathognomonic for equine herpesvirus 1 infection in mares

47
Q

why should you always get a sample of the fetus’ lungs in a fetal necropsy?

A

the lungs are reflective of the amniotic environment and you will see a lot on histo even if you see nothing grossly

48
Q

what is miliary hepatic necrosis?

A

where the liver looks like it’s been sprinkled with snow, indicitave of viremia or septicemia

49
Q

in small ruminants, targetoid hepatic necrosis in a fetal liver is typical of

A

campylobacter infections

50
Q

if a fetus has been infected with cache valley virus, what will they look like?

A

arthrogryposis (joint stiffness), and deformities of the spinal column and CNS

51
Q

why do we want a sample of the brain to look at under histo in a fetus?

A

it is the target organ in protozoal infections

VETM 425 (28 decks)

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