Pituitary Flashcards
what are the two parts of the pitutary?
adenohyphophysis and neurohypophysis
what hormones are made by the adenohypohysis?
TSH, FSH, ACTH, LH, GH
what hormones are made by the neurohypohysis?
oxytocin, ADH
if an animal has an aplaia pituitary in utero, why would the gestation time be increased?
birth is trigger by the HPA axsis in the baby, and so if they don’t have a functioning pituitary, this doesn’t work
what is vertatrum californicum?
skunk cabbage, if it is ingested at day 14 it causes a naurel tube defect and a lot of craniofacial defects such as cyclopia and aplasia or malfomration of the adenohypohysis
what is cyclopia?
craniofacial defects, their face is all effed up
you see a german shepherd puppy that us 5 months old, but it looks like it’s only about a month old. What could be going on here?
a pituitary cysts/juvenile panhypopituitarism, an autosomal recessive gene in GSDs what cause hypoadrenocorticism (no ACTH) and hypothyroidism (no TSH)
non functional pituitary neoplasms are most common in ________. Are they usually benign or malignant?
dogs and cats
usually adenomas moreso than carcinomas
if an animal had a non functional pituitary neoplasm like an adenoma, what are some diseases/clinical signs you would see and WHY?
hypothyroidism (no TSH)
hypoadrenocorticim (no ACTH)
gonadal atrophy if they aint fixed (no FSH or LH)
CNS compression (tumor pushes the brain)
wot
this is a pituitary tumor, likely a benign one/adenoma
hyperpituitarism from a corticotroph or adrenocortocotrophic hormone secreting adenoma is most common in _____. What will the adrenal glands look like ?
dogs, usually corticotrophs of the pars distalis or intermedia
because the pituitary is secreting ACTH a bunch, both of the adrneal cortesies undergoes hypertrophy/hyperplasia , causing secondary hyperfunction of the adrenal cortex
the most common pituitary tumor of horses is
melanotroph adenoma of the pars intermedia which causes PPID
breifly describe the pathogenesis of PPID in horses?
excessive production of PMOC and it’s derivatives
clinical signs are the result of hypothalmic/neurohyphohyseal dysfunction from COMPRESSION, including hypertrichosis, polyphagia, hyperglycemia, PUPD, etc
somatotroph adenomas are common in _____ and what do they cause?
cats, cause acromegaly=hypersecretion of growth hormone AKA somatotropin
cats with acromegaly have increased soft tissue and bone prolfieration. what else can happen to these cats?
insulin resistance/diabetes
