Receptors Flashcards
alpha one
- increase vascular smooth muscle contraction
- pupillary dilator muscle
- intestinal and bladder spinchter contraction
alpha two
decrease sympathetic outflow
decrease insulin release
decrease lipolysis
increase platelet aggregation
beta one
increase hr
increase contracility
increase renin
increase lipolysis
beta two
vasodilation, bronchodilation
increase hr, contractility, lipolysis
increase aqueous humor production
N receptors
ligand gated Na/K channels
M1
CNS
enteric nerve system
M2
decrease heart rate and contractility of atria
M3
increase exocrine gland secretions increase gut perstaliss increase bladder contraction bronchoconstriction increase pupillary sphinct muscler (miosis)
M receptor - classes
M1 - q
M2 - i
M3 - q
a/b Receptor Classes
a1 - q
a2 - i
b1 - s
b2 - s
D/H/V receptor classes
D - si
H - qs
V - qs
D1
relaxes RENAL vascular smooth muscle
D2
modulates transmitter release, esp in brain
H1
increases nashal and bronchial mucus production
contraction of bronchioles, pruritis, pain
H2
increase gastric acid secretion
V1
increases vascular smooth muscle contraction
V2
increases H202 permeability and reabsorption in collection tubules of the kidney
Gq
phopholipase c –> DAG + IP3
DAG –> protein kinase C
IP3 –> increase Ca in –> smooth muscle contraction
Gs/or/i
adenylyl cyclase –> camp –> protein kinase A
increase Ca (heart)
myosin light chian kinase (smooth msucle)
parts of SNS innervated by cholinergic fibers
adrenal medulla
sweat glands
Synthesis of NE
tyrosine –> dopa –> dopamine –> NE –> Epi
Botulinium toxin
prevents ach release from synaptic vesicles
Cocaine
inhibits NE reuptake
TCA
inhibts NE reuptake
Amphetamine
inhibts NE reuptake
