Biochem Flashcards
leukotriene targeted drugs
montelukast
zileutin
Rb
tumor suppressor
osteosarcoma, retinoblastoma
Niacin side effects
flushing of the face
can be aleviating by taking aspirin
Cystinuria
AR
defect in aa transporter for
cysteine, orthithine, lysine, arginine
recurrent stones
Chediak-Higashia syndrome mechanism
microtubule polymeraization defect leading to decreased phagocytosis
vincristine
Mphase specific
prevents microtubule polymeralization
Chediak HIgashi syndrome symptoms
recurrent pyogenic infections
partial albinism
vit c
proline hydroxylation in collagen synthesis
McArdle’s disease
AR
glycogen phosphorylase
increased glycogen in muscle that can’t be broken down
painful cramps, myoglobinuria
RNA polymerase I
makes rRNA
RNA polymerase II
makes mRNA
RNA polyermase III
makes tRNA
alpha-amanitin
inhibits RNA polyermase II
Kwashiorkor
protein malnutrition (tryptophan and lysine) Malnutrition, Edema, Anemia, Liver
21-hydroxylase def
decreased mc: hypotension, hyperkalemia
pseudoherm in females
17alpha-hydroxylase def
increased mc: hypertension, hypokalemia
males: ambiguous genitalia/undescended testes
females: normal, lack 2 sex characteristics
11b-hydroxylase def
decreased aldosterone, increased c: hypertension
masculinization
rate limiting enzyme of fatty acid synthesis
acetyl-CoA carboxylase
treatment for uterine leiomyomas
GnRH agonist/leuprolide
sympathetic alpha one
increases vascular smooth muscle contraction
Gq (phospholipase c)
phospholipase C
PIP2 –> Dag and IP3
DAG
protein kinase 3
IP3
Ca –> smooth muscle contraction
sympathetic alpha two
decreased sympathetic outflow
qi (adenylyl cylase)