Immune System

Question 1

Post-splenectomy

Answer 1

Howell-Jolly bodies
target cells
thrombocytosis

Question 2

Positive Selection

Answer 2

thymus, cortex

MHC restriction

Question 3

Negative Selection

Answer 3

thymus, medulla

non reactive to self

Question 4

HLA A3

Answer 4

Hemochromatosis

Question 5

HLA-DQ2/8

Answer 5

Celiac Disease

Question 6

HLA-DR5

Answer 6

pernicious anemia/b12 def

hashimoto’s thyroidits

Question 7

NK cells

Answer 7

induce apoptosis of virally infected and tumor cells

Question 8

Th1/Th2 secretes

Answer 8

Th1 - ifn gamma

Th2 - IL-4,5,10,13

Question 9

Th1/Th2 activates

Answer 9

th1 - macrophages

th2 - eosinophil, Ige production

Question 10

Th1 inhibited by

Answer 10

IL4 and IL10

Question 11

th2 inhibited by

Answer 11

IFN-gamma

Question 12

SCID

Answer 12

infant, agammaglobulenima, lymphopenia

Question 13

SCID cause

Answer 13

defective IL-2 receptor
adenosine deaminase def
X-linked

Question 14

SCID treatment

Answer 14

BMT

Question 15

Wiskott-Aldrich Syndrome

Answer 15

Thrombocytopenia
infections
Eczema
combined B and T cell def

Question 16

cause of Wiskott-Aldrich Syndrome

Answer 16

X linked, WAS gene

T cells unable to reorganize actin skeleton

Question 17

Ataxia-telangiectasia

Answer 17

cerebellar defects - ataxia
spider angiomas - telangiectasia
IgA def
increased AFP

Question 18

Ataxia-telangiectasia cause

Answer 18

defects in ATM gene, codes for DNA repair

Question 19

Hyper IgM sydrome

Answer 19

severe pyogenic infections early in life
defective CD40L on Helper T cells/inability to class switch

Question 20

Leukocyte adhesion def

Answer 20

recurrent bacterial infections
perstistent neutrophilia
absent pus
delayed separation of umbilical cord

Question 21

Cause of Leukocyte adhesion def

Answer 21

defect in LFA-1 integrin on phagocytes

Question 22

Chediak-Higashi syndrome

Answer 22

recurrent infections - catalase positive
AR
microtubule dysfunction in phagosome-lyosome fusion

Question 23

Chronic Ganulomatous disease

Answer 23

boy
catalase + infections
Abnormal DHR flow cyto test or nitroblue tetrazoliume

Question 24

catalse poisitve organisms

Answer 24

S aeures, E coli
Serratia
Aspergillus

Question 25

Chronic Granulomatous dz causes

Answer 25

lack of NADPH oxidase --> decrease of ROS

Question 26

X-linked agammaglobulinemia

Answer 26

infant boy, 4-6 months encapsulated organism sepsis absent B cells

Question 27

cause of X linked agammaglobulinemia

Answer 27

X linked recessive/defect in BTK/no B cell maturation

Question 28

Selegtive IgA def

Answer 28

asymptomatic anaphylaxis to IgA-containing blood products false positive B-HCG tests

Question 29

CVID

Answer 29

young adults recurrent sinusitis, pneumonia, bronchiectasis splenomegaly, malignacies, GI absorption

Question 30

CVID labs

Answer 30

decreased plasma cells

Question 31

DiGeorge syndrome cause

Answer 31

22q deletion | failure to develop 3rd and 4th pharyngeal pouches

Question 32

DiGeorge Syndrome

Answer 32

CHD - truncus arterosus facial abnormalities low Ca (PTH) and T cells

Question 33

IL-12 receptor def

Answer 33

decreased Th1 response | disseminated mycobacterial infections

Question 34

Hyper-IgE syndrome cause

Answer 34

neutrophils can't respond to chemotactic stimuli | no IFN-gamma from TH1 cells

Question 35

Hyper IgE syndrome

Answer 35

``` FATED: coarse facies, cold staphylcoccal absecess retained primary teeth increased IgE dermatological problems/exzema ```

Question 36

Chronic Mucocutaneous candidias

Answer 36

T cell dysfunction

Question 37

Cyclosporine

Answer 37

binds to cyclophilin suppress organ rejection nephrotox, HTN, hirsuitism

Question 38

Tacrolimus

Answer 38

binds FK-binding protein

Question 39

Sirolimus

Answer 39

inhibits mTOR | hyperlipidemia

Question 40

Azathioprine

Answer 40

interferes with synthesis of nucleic acids | toxicity increased by allopurinol

Question 41

Muromonab

Answer 41

binds to CD3 on T cells | prevent acute transplant rejection

Question 42

Digoxin Immune Fab

Answer 42

antidote for dogoxin intox

Question 43

Abciximab

Answer 43

Glycoprotein IIb/IIIa | prevent cardiac ischemia

Question 44

Rituximab

Answer 44

CD20, B Cell non-Hodgkin's lymphoma

Question 45

Omalizumab

Answer 45

IgE, asthma

Question 46

Adesleukin

Answer 46

interluekin-2 | renall cell carcinoma, metastatic melnoma

Question 47

epoetin alfa

Answer 47

erythopoietin | anemias

Question 48

filgrastim

Answer 48

granulocyte colon-stimulating factor | recovery of bone marrow

Question 49

sargramostim

Answer 49

granulocyte-macrophage colony stimulating factor | recovery of bone marrow

Question 50

alpha interferon

Answer 50

hep B and C kaposi's sarcoma leukemias malignant melanoma

Question 51

beta interferon

Answer 51

multiple sclerosis

Question 52

gamma interferon

Answer 52

chronic granulomatous dz

Question 53

oprelvekin

Answer 53

thrombocytopenia

Question 54

thrombopoietin

Answer 54

thrombocytopenia

Question 55

chronic transplant rejection

Answer 55

months/years | Class-1 MHCnon self perceived as self present a non-self antigen

Question 56

febrile nonhemolytic transfusion reaction

Answer 56

type II hypersen fever and chills against HLA antigens and leukocytes

Question 57

anti-U1 RNP

Answer 57

mixed CT dz

Question 58

anti-glutamate decarboxylase

Answer 58

T1DM

Question 59

examples of passive immunity

Answer 59

tetanus toxin botulinum toxn HBV rabies

Question 60

C1 esterase inhibitor def

Answer 60

hereditary angioedema | ACE inhibitors contraindictored

Question 61

DAF/GPI anchored enzyme def

Answer 61

paroxysmal noctural hemoglobinuria

Question 62

IL-1

Answer 62

fever

Question 63

IL-2

Answer 63

T cells

Question 64

IL-3

Answer 64

bone marrow

Question 65

IL-4

Answer 65

IgE

Question 66

IL-5

Answer 66

IgA

Question 67

IL-8

Answer 67

neutrophils

Question 68

IL-12

Answer 68

activates NK cells