Ranitidine

Question 1

Class

Answer 1

Histamine H2 receptor

antagonist

Question 2

Actions

Answer 2

Inhibits gastric acid
secretion
Inhibits action of
histamine releae from
mast cell-like cells in
the gastric mucosa
Partilally inhibits acid
secretion stimulated
by gastrin or vagal
timulation

Question 3

Mechanism of Action

Answer 3

Selective, reversible and
competitive antagonism of
Histamine H2 receptors on
parietal cells

Question 4

Clinical Use

Answer 4

Peptic and duodenal
ulcers
Gastro-oesophageal
reflux disease
NSAID induced ulcers

Question 5

Adverse effects

Answer 5

Uncommon
Headache, GIT
disturbances
Confusion,
disorientation in
elderly
Antiandrogenic effects
with cimetidine

Question 6

what is Ranitidine and where does it act?

Answer 6

Ranitidine is a competitive inhibitor of histamine on parietal cells in the stomach

Question 7

what effect does Ranitidine have on the parietal cells in the stomach

Answer 7

decreasing acid production

Question 8

what is Ranitidine an example of?

Answer 8

an inverse agonists rather than a true receptor antagonists.

Question 9

how does Ranitidine reduce stomach acid?

Answer 9

1) Blocking histamine binding
2) Reduce the effect of other substances that promote acid secretion (such as gastrin and acetylcholine) on parietal cells.

Question 10

why is Ranitidine not used so much anymore?

Answer 10

their use has waned since the advent of the more effective proton pump inhibitors.

Question 11

what is Ranitidine used to treat

Answer 11

dyspepsia