Metronidazole

Question 1

Class

Answer 1

Amoebicide

Question 2

Action

Answer 2

Kills the motile forms
of entamoeba
histolytica

Question 3

Mechanism of Action

Answer 3

The trophozoite generates
from the drugs, free
radicals that damage the
trophozoite’s DNA

Question 4

Clinical Use

Answer 4

Amoebic dysentry
Ameobic liver abscess
Trichomniasis
Giardiasis

Question 5

Adverse effects

Answer 5

GI disturbances
Anorexia
Dizziness
Ataxia
Disulfiram reactions
after alcohol

Question 6

what is metronidazole

Answer 6

A Nitroimidazole antibacterial and antiprotozoal

Question 7

what organisms is metronidazole used against?

Answer 7

protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis.

Question 8

what is metronidazole specifically effective against

Answer 8

anaerobic bacterial infections

Question 9

what is metrodazole also used to treat?

Answer 9

Crohn’s disease, antibiotic-associated diarrhea, and rosacea.

Question 10

how does metronidazole act to cause cell death in bacteria

Answer 10

Unionized metronidazole is taken up by anaerobic bacteria, and is then reduced to its active form. This reduced metronidazole then covalently binds to DNA, disrupting its helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death.