Bezafibrate Flashcards
what is bezafibrate
An antilipemic agent
how does bezafibrate lower chlesterol and triglycerides?
via activation of triglyceride lipases and reduction of cholesterol biosynthesis
what are the triglyceride lipases?
lipoprotein lipase and hepatic lipoprotein lipase
what are the triglyceride lipases involved in
the catabolism of triglyceride-rich lipoproteins
what happens when elevated VLDL and LDL levels are reduced?
formation of increased concentrations of HDL precursors leading to an increase in HDL-levels.
what is elevated fibrinogen is an important risk-factor in
development of atheroma
thrombus development and lysability
why is elevated fibrinogen is an important risk-factor in the development of atheroma?
due to its role in blood flow and viscosity
what can bezafibrate can cause a significant decrease in?
elevated plasma fibrinogen levels
