Domperidone Flashcards
1
Q
Which receptors does Domperidone inhibit
A
Domperidone inhibits the dopamine receptor (D2 and D3) in the chemoreceptor trigger zone
2
Q
where are the chemoreceptor trigger zone
A
located just outside the blood brain barrier
3
Q
what are the other acts of domperidone
A
Domperidone also acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant.
4
Q
Class
A
D2 receptor antagonist
5
Q
Action
A
Antiemetic
Antipsychotic
6
Q
Mechanisms of Actions
A
Reversible competitive
antagonism of D2
receptors
7
Q
Clinical Uses
A
Nausea and vomiting associated with cancer chemotherapy Radiation therapy and general anaesthesia
8
Q
Adverse Effects
A
Extrapyramidal effects Parkinsonian symptoms Hypotension Antihistamine and antimuscarinic actions
