Metoclopramide

Question 1

What is Metoclopramide

Answer 1

Metoclopramide is a dopamine receptor antagonists. Therefore . In addition high doses of metoclopramideMetoclopramide can also inhibits gastric smooth muscle relaxation produced by dopamine, therefore increasing cholinergic

Question 2

what is the significance of Metoclopramide being a dopamine receptor antagoist

Answer 2

it raises the threshold of activity in the chemoreceptor trigger zone and decreases the input from afferent visceral nerves

Question 3

what effect does high does of metoclopramide have on the body?

Answer 3

can antagonize 5-hydroxytryptamine (5-HT) receptors in the peripheral nervous system.

Question 4

how does metoclopramide decrease reflux into the oesophagus

Answer 4

by increasing the resting pressure of the lower oesophageal sphincter

Question 5

how does metoclopramide improve acid clearance from the oesophagus

Answer 5

by increasing amplitude of oesophageal peristaltic contractions.

Question 6

how does metoclopramide affect gastric smooth muscle?

Answer 6

inhibits gastric smooth muscle relaxation produced by dopamine, therefore increasing cholinergic response of the gastrointestinal smooth muscle.

Question 7

Class

Answer 7

D2 receptor antagonist

Question 8

Action

Answer 8

Antiemetic

Antipsychotic

Question 9

Mechanisms of Actions

Answer 9

Reversible competitive
antagonism of D2
receptors

Question 10

Clinical Uses

Answer 10

Nausea and vomiting
associated with cancer
chemotherapy
Radiation therapy and
general anaesthesia

Question 11

Adverse Effects

Answer 11

Extrapyramidal effects
Parkinsonian
symptoms
Hypotension
Antihistamine and
antimuscarinic actions