Esomeprazole Flashcards
1
Q
Class
A
Proton pump inhibitor
2
Q
Actions
A
Inhibition of gastric
acid secretion
3
Q
Mechanism of Action
A
Binds irreversibly to H+/K+ ATPase in the gastric parietal cells to inhibit H+ transport Is a prodrug Acdiic conditions convert the drug to the active form
4
Q
Clinical Use
A
Duodenal and peptic ulcer Gasto-oesophegal refux disease Treatment of NSAID associated ulcers More effective than H2 antagonists
5
Q
Adverse effects
A
Generally bery safe Occasionally headache, abdominal pain, diarrohea, flatulence and nausea. Long-term use can cause hypergastrininaemia
6
Q
what does Esomeprazole do?
A
Inhibits gastric acid secretion
7
Q
what is Esomeprazole used to treat?
A
indicated in the treatment of gastroesophageal reflux disease (GERD), and H. pylori eradication to reduce the risk of duodenal ulcer recurrence
8
Q
what new class of antisecretory compounds is Esomeprazole in?
A
, the substituted benzimidazoles that do not exhibit anticholinergic or H2 histamine antagonistic properties, but that target specifically the H+/K+ ATPase in the gastric parietal cell
