Perphenazine

Question 1

What is Perphenazine

Answer 1

a piperazinyl phenothiazine

Question 2

What is the difference between Perphenazine and chlorpromazine

Answer 2

Perphenazine is 10 to 15 times as potent as chlorpromazine

Question 3

which receptors does Perphenazine inhibit

Answer 3

the dopamine D1 and dopamine D2 receptors and the alpha andrenergic receptor

Question 4

how does Perphenzine have anti-emetic effect

Answer 4

due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre

Question 5

what is the difference between Perphenazine and the other phenothiazine derivatives

Answer 5

Perphenazine has a greater behavioural potency than other phenothiazine derivatives.

Question 6

what type of alpha andrenergic receptor does Perphenazine bind to?

Answer 6

the alpha andrenergic receptor that activate a phosphatidylinositol-calcium second messenger system.

Question 7

Class

Answer 7

Antipsychotic drug

Question 8

Action

Answer 8

Reduced agression

Antiemetic

Question 9

Mechanisms of Actions

Answer 9

Competitive antagonism of
dopamine D2 receptors in
the
mesolimbic/mesocortical
pathways

Question 10

Clinical Uses

Answer 10

Schizoprhrenia
Manic phase of bipolar
disorder
Tourette’s syndrome
Nausea and vomitting
Persistent hiccups

Question 11

Adverse Effects

Answer 11

Marked sedation
Endocrine effects
Antimuscarinic effects
Hypotension